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Focal Laser Ablation of Prostate Cancer: Definition, Needs, and Future
Current challenges and innovations in prostate cancer management concern the development of focal therapies that allow the treatment of only the cancer areas sparing the rest of the gland to minimize the potential morbidity. Among these techniques, focal laser ablation (FLA) appears as a potential c...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3362007/ https://www.ncbi.nlm.nih.gov/pubmed/22666240 http://dx.doi.org/10.1155/2012/589160 |
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author | Colin, Pierre Mordon, Serge Nevoux, Pierre Marqa, Mohammed Feras Ouzzane, Adil Puech, Philippe Bozzini, Gregory Leroux, Bertrand Villers, Arnauld Betrouni, Nacim |
author_facet | Colin, Pierre Mordon, Serge Nevoux, Pierre Marqa, Mohammed Feras Ouzzane, Adil Puech, Philippe Bozzini, Gregory Leroux, Bertrand Villers, Arnauld Betrouni, Nacim |
author_sort | Colin, Pierre |
collection | PubMed |
description | Current challenges and innovations in prostate cancer management concern the development of focal therapies that allow the treatment of only the cancer areas sparing the rest of the gland to minimize the potential morbidity. Among these techniques, focal laser ablation (FLA) appears as a potential candidate to reach the goal of focusing energy delivery on the identified targets. The aim of this study is to perform an up-to-date review of this new therapeutic modality. Relevant literature was identified using MEDLINE database with no language restrictions (entries: focal therapy, laser interstitial thermotherapy, prostate cancer, FLA) and by cross-referencing from previously identified studies. Precision, real-time monitoring, MRI compatibility, and low cost of integrated system are principal advantages of FLA. Feasibility and safety of this technique have been reported in phase I assays. FLA might eventually prove to be a middle ground between active surveillance and radical treatment. In conclusion, FLA may have found a role in the management of prostate cancer. However, further trials are required to demonstrate the oncologic effectiveness in the long term. |
format | Online Article Text |
id | pubmed-3362007 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-33620072012-06-04 Focal Laser Ablation of Prostate Cancer: Definition, Needs, and Future Colin, Pierre Mordon, Serge Nevoux, Pierre Marqa, Mohammed Feras Ouzzane, Adil Puech, Philippe Bozzini, Gregory Leroux, Bertrand Villers, Arnauld Betrouni, Nacim Adv Urol Review Article Current challenges and innovations in prostate cancer management concern the development of focal therapies that allow the treatment of only the cancer areas sparing the rest of the gland to minimize the potential morbidity. Among these techniques, focal laser ablation (FLA) appears as a potential candidate to reach the goal of focusing energy delivery on the identified targets. The aim of this study is to perform an up-to-date review of this new therapeutic modality. Relevant literature was identified using MEDLINE database with no language restrictions (entries: focal therapy, laser interstitial thermotherapy, prostate cancer, FLA) and by cross-referencing from previously identified studies. Precision, real-time monitoring, MRI compatibility, and low cost of integrated system are principal advantages of FLA. Feasibility and safety of this technique have been reported in phase I assays. FLA might eventually prove to be a middle ground between active surveillance and radical treatment. In conclusion, FLA may have found a role in the management of prostate cancer. However, further trials are required to demonstrate the oncologic effectiveness in the long term. Hindawi Publishing Corporation 2012 2012-05-16 /pmc/articles/PMC3362007/ /pubmed/22666240 http://dx.doi.org/10.1155/2012/589160 Text en Copyright © 2012 Pierre Colin et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Colin, Pierre Mordon, Serge Nevoux, Pierre Marqa, Mohammed Feras Ouzzane, Adil Puech, Philippe Bozzini, Gregory Leroux, Bertrand Villers, Arnauld Betrouni, Nacim Focal Laser Ablation of Prostate Cancer: Definition, Needs, and Future |
title | Focal Laser Ablation of Prostate Cancer: Definition, Needs, and Future |
title_full | Focal Laser Ablation of Prostate Cancer: Definition, Needs, and Future |
title_fullStr | Focal Laser Ablation of Prostate Cancer: Definition, Needs, and Future |
title_full_unstemmed | Focal Laser Ablation of Prostate Cancer: Definition, Needs, and Future |
title_short | Focal Laser Ablation of Prostate Cancer: Definition, Needs, and Future |
title_sort | focal laser ablation of prostate cancer: definition, needs, and future |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3362007/ https://www.ncbi.nlm.nih.gov/pubmed/22666240 http://dx.doi.org/10.1155/2012/589160 |
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