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Pulse Wave Velocity as Marker of Preclinical Arterial Disease: Reference Levels in a Uruguayan Population Considering Wave Detection Algorithms, Path Lengths, Aging, and Blood Pressure

Carotid-femoral pulse wave velocity (PWV) has emerged as the gold standard for non-invasive evaluation of aortic stiffness; absence of standardized methodologies of study and lack of normal and reference values have limited a wider clinical implementation. This work was carried out in a Uruguayan (S...

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Autores principales: Farro, Ignacio, Bia, Daniel, Zócalo, Yanina, Torrado, Juan, Farro, Federico, Florio, Lucía, Olascoaga, Alicia, Alallón, Walter, Lluberas, Ricardo, Armentano, Ricardo L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3362057/
https://www.ncbi.nlm.nih.gov/pubmed/22666551
http://dx.doi.org/10.1155/2012/169359
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author Farro, Ignacio
Bia, Daniel
Zócalo, Yanina
Torrado, Juan
Farro, Federico
Florio, Lucía
Olascoaga, Alicia
Alallón, Walter
Lluberas, Ricardo
Armentano, Ricardo L.
author_facet Farro, Ignacio
Bia, Daniel
Zócalo, Yanina
Torrado, Juan
Farro, Federico
Florio, Lucía
Olascoaga, Alicia
Alallón, Walter
Lluberas, Ricardo
Armentano, Ricardo L.
author_sort Farro, Ignacio
collection PubMed
description Carotid-femoral pulse wave velocity (PWV) has emerged as the gold standard for non-invasive evaluation of aortic stiffness; absence of standardized methodologies of study and lack of normal and reference values have limited a wider clinical implementation. This work was carried out in a Uruguayan (South American) population in order to characterize normal, reference, and threshold levels of PWV considering normal age-related changes in PWV and the prevailing blood pressure level during the study. A conservative approach was used, and we excluded symptomatic subjects; subjects with history of cardiovascular (CV) disease, diabetes mellitus or renal failure; subjects with traditional CV risk factors (other than age and gender); asymptomatic subjects with atherosclerotic plaques in carotid arteries; patients taking anti-hypertensives or lipid-lowering medications. The included subjects (n = 429) were categorized according to the age decade and the blood pressure levels (at study time). All subjects represented the “reference population”; the group of subjects with optimal/normal blood pressures levels at study time represented the “normal population.” Results. Normal and reference PWV levels were obtained. Differences in PWV levels and aging-associated changes were obtained. The obtained data could be used to define vascular aging and abnormal or disease-related arterial changes.
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spelling pubmed-33620572012-06-04 Pulse Wave Velocity as Marker of Preclinical Arterial Disease: Reference Levels in a Uruguayan Population Considering Wave Detection Algorithms, Path Lengths, Aging, and Blood Pressure Farro, Ignacio Bia, Daniel Zócalo, Yanina Torrado, Juan Farro, Federico Florio, Lucía Olascoaga, Alicia Alallón, Walter Lluberas, Ricardo Armentano, Ricardo L. Int J Hypertens Research Article Carotid-femoral pulse wave velocity (PWV) has emerged as the gold standard for non-invasive evaluation of aortic stiffness; absence of standardized methodologies of study and lack of normal and reference values have limited a wider clinical implementation. This work was carried out in a Uruguayan (South American) population in order to characterize normal, reference, and threshold levels of PWV considering normal age-related changes in PWV and the prevailing blood pressure level during the study. A conservative approach was used, and we excluded symptomatic subjects; subjects with history of cardiovascular (CV) disease, diabetes mellitus or renal failure; subjects with traditional CV risk factors (other than age and gender); asymptomatic subjects with atherosclerotic plaques in carotid arteries; patients taking anti-hypertensives or lipid-lowering medications. The included subjects (n = 429) were categorized according to the age decade and the blood pressure levels (at study time). All subjects represented the “reference population”; the group of subjects with optimal/normal blood pressures levels at study time represented the “normal population.” Results. Normal and reference PWV levels were obtained. Differences in PWV levels and aging-associated changes were obtained. The obtained data could be used to define vascular aging and abnormal or disease-related arterial changes. Hindawi Publishing Corporation 2012 2012-05-16 /pmc/articles/PMC3362057/ /pubmed/22666551 http://dx.doi.org/10.1155/2012/169359 Text en Copyright © 2012 Ignacio Farro et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Farro, Ignacio
Bia, Daniel
Zócalo, Yanina
Torrado, Juan
Farro, Federico
Florio, Lucía
Olascoaga, Alicia
Alallón, Walter
Lluberas, Ricardo
Armentano, Ricardo L.
Pulse Wave Velocity as Marker of Preclinical Arterial Disease: Reference Levels in a Uruguayan Population Considering Wave Detection Algorithms, Path Lengths, Aging, and Blood Pressure
title Pulse Wave Velocity as Marker of Preclinical Arterial Disease: Reference Levels in a Uruguayan Population Considering Wave Detection Algorithms, Path Lengths, Aging, and Blood Pressure
title_full Pulse Wave Velocity as Marker of Preclinical Arterial Disease: Reference Levels in a Uruguayan Population Considering Wave Detection Algorithms, Path Lengths, Aging, and Blood Pressure
title_fullStr Pulse Wave Velocity as Marker of Preclinical Arterial Disease: Reference Levels in a Uruguayan Population Considering Wave Detection Algorithms, Path Lengths, Aging, and Blood Pressure
title_full_unstemmed Pulse Wave Velocity as Marker of Preclinical Arterial Disease: Reference Levels in a Uruguayan Population Considering Wave Detection Algorithms, Path Lengths, Aging, and Blood Pressure
title_short Pulse Wave Velocity as Marker of Preclinical Arterial Disease: Reference Levels in a Uruguayan Population Considering Wave Detection Algorithms, Path Lengths, Aging, and Blood Pressure
title_sort pulse wave velocity as marker of preclinical arterial disease: reference levels in a uruguayan population considering wave detection algorithms, path lengths, aging, and blood pressure
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3362057/
https://www.ncbi.nlm.nih.gov/pubmed/22666551
http://dx.doi.org/10.1155/2012/169359
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