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N-Domain Isoform of Angiotensin I Converting Enzyme as a Marker of Hypertension: Populational Study

The aim of this paper was to investigate the presence of the urinary 90 kDa N-domain ACE in a cohort of the population from Vitoria, Brazil, to verify its association with essential hypertension since this isoform could be a possible genetic marker of hypertension. Anthropometric, clinical, and labo...

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Autores principales: Maluf-Meiken, Leila C. V., Fernandes, Fernanda B., Aragão, Danielle S., Ronchi, Fernanda A., Andrade, Maria C. C., Franco, Maria C., Febba, Andreia C. S., Plavnik, Frida L., Krieger, José E., Mill, Jose G., Sesso, Ricardo C. C., Casarini, Dulce E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3362081/
https://www.ncbi.nlm.nih.gov/pubmed/22666552
http://dx.doi.org/10.1155/2012/581780
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author Maluf-Meiken, Leila C. V.
Fernandes, Fernanda B.
Aragão, Danielle S.
Ronchi, Fernanda A.
Andrade, Maria C. C.
Franco, Maria C.
Febba, Andreia C. S.
Plavnik, Frida L.
Krieger, José E.
Mill, Jose G.
Sesso, Ricardo C. C.
Casarini, Dulce E.
author_facet Maluf-Meiken, Leila C. V.
Fernandes, Fernanda B.
Aragão, Danielle S.
Ronchi, Fernanda A.
Andrade, Maria C. C.
Franco, Maria C.
Febba, Andreia C. S.
Plavnik, Frida L.
Krieger, José E.
Mill, Jose G.
Sesso, Ricardo C. C.
Casarini, Dulce E.
author_sort Maluf-Meiken, Leila C. V.
collection PubMed
description The aim of this paper was to investigate the presence of the urinary 90 kDa N-domain ACE in a cohort of the population from Vitoria, Brazil, to verify its association with essential hypertension since this isoform could be a possible genetic marker of hypertension. Anthropometric, clinical, and laboratory parameters of the individuals were evaluated (n = 1150) and the blood pressure (BP) was measured. The study population was divided according to ACE isoforms in urine as follows: ACE 65/90/190, presence of three ACE isoforms (n = 795), ACE 90(+) (65/90) (n = 186), and ACE 90(−) (65/190) (n = 169) based on the presence (+) or absence (−) of the 90 kDa ACE isoform. The anthropometric parameters, lipid profile, serum levels of uric acid, glucose, and the systolic and diastolic BP were significantly greater in the ACE 90(+) compared with the ACE 90(−) and ACE 65/90/190 individuals. We found that 98% of individuals from the ACE 90(+) group and 38% from the ACE 65/90/190 group had hypertension, compared to only 1% hypertensive individuals in the ACE 90(−) group. There is a high presence of the 90 kDa N-domain ACE isoform (85%) in the studied population. The percentile of normotensive subjects with three isoforms was 62%. Our findings could contribute to the development of new efficient strategy to prevent and treat hypertension to avoid the development of cardiovascular disease.
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spelling pubmed-33620812012-06-04 N-Domain Isoform of Angiotensin I Converting Enzyme as a Marker of Hypertension: Populational Study Maluf-Meiken, Leila C. V. Fernandes, Fernanda B. Aragão, Danielle S. Ronchi, Fernanda A. Andrade, Maria C. C. Franco, Maria C. Febba, Andreia C. S. Plavnik, Frida L. Krieger, José E. Mill, Jose G. Sesso, Ricardo C. C. Casarini, Dulce E. Int J Hypertens Clinical Study The aim of this paper was to investigate the presence of the urinary 90 kDa N-domain ACE in a cohort of the population from Vitoria, Brazil, to verify its association with essential hypertension since this isoform could be a possible genetic marker of hypertension. Anthropometric, clinical, and laboratory parameters of the individuals were evaluated (n = 1150) and the blood pressure (BP) was measured. The study population was divided according to ACE isoforms in urine as follows: ACE 65/90/190, presence of three ACE isoforms (n = 795), ACE 90(+) (65/90) (n = 186), and ACE 90(−) (65/190) (n = 169) based on the presence (+) or absence (−) of the 90 kDa ACE isoform. The anthropometric parameters, lipid profile, serum levels of uric acid, glucose, and the systolic and diastolic BP were significantly greater in the ACE 90(+) compared with the ACE 90(−) and ACE 65/90/190 individuals. We found that 98% of individuals from the ACE 90(+) group and 38% from the ACE 65/90/190 group had hypertension, compared to only 1% hypertensive individuals in the ACE 90(−) group. There is a high presence of the 90 kDa N-domain ACE isoform (85%) in the studied population. The percentile of normotensive subjects with three isoforms was 62%. Our findings could contribute to the development of new efficient strategy to prevent and treat hypertension to avoid the development of cardiovascular disease. Hindawi Publishing Corporation 2012 2012-05-15 /pmc/articles/PMC3362081/ /pubmed/22666552 http://dx.doi.org/10.1155/2012/581780 Text en Copyright © 2012 Leila C. V. Maluf-Meiken et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Study
Maluf-Meiken, Leila C. V.
Fernandes, Fernanda B.
Aragão, Danielle S.
Ronchi, Fernanda A.
Andrade, Maria C. C.
Franco, Maria C.
Febba, Andreia C. S.
Plavnik, Frida L.
Krieger, José E.
Mill, Jose G.
Sesso, Ricardo C. C.
Casarini, Dulce E.
N-Domain Isoform of Angiotensin I Converting Enzyme as a Marker of Hypertension: Populational Study
title N-Domain Isoform of Angiotensin I Converting Enzyme as a Marker of Hypertension: Populational Study
title_full N-Domain Isoform of Angiotensin I Converting Enzyme as a Marker of Hypertension: Populational Study
title_fullStr N-Domain Isoform of Angiotensin I Converting Enzyme as a Marker of Hypertension: Populational Study
title_full_unstemmed N-Domain Isoform of Angiotensin I Converting Enzyme as a Marker of Hypertension: Populational Study
title_short N-Domain Isoform of Angiotensin I Converting Enzyme as a Marker of Hypertension: Populational Study
title_sort n-domain isoform of angiotensin i converting enzyme as a marker of hypertension: populational study
topic Clinical Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3362081/
https://www.ncbi.nlm.nih.gov/pubmed/22666552
http://dx.doi.org/10.1155/2012/581780
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