A Model of DENV-3 Infection That Recapitulates Severe Disease and Highlights the Importance of IFN-γ in Host Resistance to Infection

There are few animal models of dengue infection, especially in immunocompetent mice. Here, we describe alterations found in adult immunocompetent mice inoculated with an adapted Dengue virus (DENV-3) strain. Infection of mice with the adapted DENV-3 caused inoculum-dependent lethality that was prece...

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Detalles Bibliográficos
Autores principales: Costa, Vivian V., Fagundes, Caio T., Valadão, Deborah F., Cisalpino, Daniel, Dias, Ana Carolina F., Silveira, Kátia D., Kangussu, Lucas M., Ávila, Thiago V., Bonfim, Maria Rosa Q., Bonaventura, Daniela, Silva, Tarcília A., Sousa, Lirlândia P., Rachid, Milene A., Vieira, Leda Q., Menezes, Gustavo B., de Paula, Ana Maria, Atrasheuskaya, Alena, Ignatyev, George, Teixeira, Mauro M., Souza, Danielle G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3362616/
https://www.ncbi.nlm.nih.gov/pubmed/22666512
http://dx.doi.org/10.1371/journal.pntd.0001663

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