Novel Mechanism of Action on Hedgehog Signaling by a Suppressor of Fused Carboxy Terminal Variant

The Suppressor of Fused (SUFU) protein plays an essential role in the Hedgehog (HH) signaling pathway, by regulation of the GLI transcription factors. Two major isoforms of human SUFU are known, a full-length (SUFU-FL) and a carboxy-terminal truncated (SUFU- ΔC) variant. Even though SUFU- ΔC is expr...

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Detalles Bibliográficos
Autores principales: Tostar, Ulrica, Finta, Csaba, Rahman, Mohammed Ferdous-Ur, Shimokawa, Takashi, Zaphiropoulos, Peter G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3362617/
https://www.ncbi.nlm.nih.gov/pubmed/22666390
http://dx.doi.org/10.1371/journal.pone.0037761

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3362617/
https://www.ncbi.nlm.nih.gov/pubmed/22666390
http://dx.doi.org/10.1371/journal.pone.0037761

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