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Reflections upon human cancer immune responsiveness to T cell-based therapy
Immune-mediated rejection of human cancer is a relatively rare but well-documented phenomenon. Its rate of occurrence progressively increases from the occasional observation of spontaneous regressions to the high rate of complete remissions observed in response to effective treatments. For two decad...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer-Verlag
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3362724/ https://www.ncbi.nlm.nih.gov/pubmed/22576055 http://dx.doi.org/10.1007/s00262-012-1274-9 |
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author | Wang, Ena Tomei, Sara Marincola, Francesco M. |
author_facet | Wang, Ena Tomei, Sara Marincola, Francesco M. |
author_sort | Wang, Ena |
collection | PubMed |
description | Immune-mediated rejection of human cancer is a relatively rare but well-documented phenomenon. Its rate of occurrence progressively increases from the occasional observation of spontaneous regressions to the high rate of complete remissions observed in response to effective treatments. For two decades, our group has focused its interest in understanding this phenomenon by studying humans following an inductive approach. Sticking to a sequential logic, we dissected the phenomenon by studying to the best of our capability both peripheral and tumor samples and reached the conclusion that immune-mediated cancer rejection is a facet of autoimmunity where the target tissue is the cancer itself. As we are currently defining the strategy to effectively identify the mechanisms leading in individual patients to rejection of their own tumors, we considered useful to summarize the thought process that guided us to our own interpretation of the mechanisms of immune responsiveness. |
format | Online Article Text |
id | pubmed-3362724 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Springer-Verlag |
record_format | MEDLINE/PubMed |
spelling | pubmed-33627242012-06-13 Reflections upon human cancer immune responsiveness to T cell-based therapy Wang, Ena Tomei, Sara Marincola, Francesco M. Cancer Immunol Immunother Opinion Paper Immune-mediated rejection of human cancer is a relatively rare but well-documented phenomenon. Its rate of occurrence progressively increases from the occasional observation of spontaneous regressions to the high rate of complete remissions observed in response to effective treatments. For two decades, our group has focused its interest in understanding this phenomenon by studying humans following an inductive approach. Sticking to a sequential logic, we dissected the phenomenon by studying to the best of our capability both peripheral and tumor samples and reached the conclusion that immune-mediated cancer rejection is a facet of autoimmunity where the target tissue is the cancer itself. As we are currently defining the strategy to effectively identify the mechanisms leading in individual patients to rejection of their own tumors, we considered useful to summarize the thought process that guided us to our own interpretation of the mechanisms of immune responsiveness. Springer-Verlag 2012-05-11 2012 /pmc/articles/PMC3362724/ /pubmed/22576055 http://dx.doi.org/10.1007/s00262-012-1274-9 Text en © The Author(s) 2012 https://creativecommons.org/licenses/by/4.0/ This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited. |
spellingShingle | Opinion Paper Wang, Ena Tomei, Sara Marincola, Francesco M. Reflections upon human cancer immune responsiveness to T cell-based therapy |
title | Reflections upon human cancer immune responsiveness to T cell-based therapy |
title_full | Reflections upon human cancer immune responsiveness to T cell-based therapy |
title_fullStr | Reflections upon human cancer immune responsiveness to T cell-based therapy |
title_full_unstemmed | Reflections upon human cancer immune responsiveness to T cell-based therapy |
title_short | Reflections upon human cancer immune responsiveness to T cell-based therapy |
title_sort | reflections upon human cancer immune responsiveness to t cell-based therapy |
topic | Opinion Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3362724/ https://www.ncbi.nlm.nih.gov/pubmed/22576055 http://dx.doi.org/10.1007/s00262-012-1274-9 |
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