The Emerging Role of PEDF in Stem Cell Biology

Encoded by a single gene, PEDF is a 50 kDa glycoprotein that is highly conserved and is widely expressed among many tissues. Most secreted PEDF deposits within the extracellular matrix, with cell-type-specific functions. While traditionally PEDF is known as a strong antiangiogenic factor, more recen...

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Detalles Bibliográficos
Autores principales: Elahy, Mina, Baindur-Hudson, Swati, Dass, Crispin R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3362874/
https://www.ncbi.nlm.nih.gov/pubmed/22675247
http://dx.doi.org/10.1155/2012/239091
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author Elahy, Mina
Baindur-Hudson, Swati
Dass, Crispin R.
author_facet Elahy, Mina
Baindur-Hudson, Swati
Dass, Crispin R.
author_sort Elahy, Mina
collection PubMed
description Encoded by a single gene, PEDF is a 50 kDa glycoprotein that is highly conserved and is widely expressed among many tissues. Most secreted PEDF deposits within the extracellular matrix, with cell-type-specific functions. While traditionally PEDF is known as a strong antiangiogenic factor, more recently, as this paper highlights, PEDF has been linked with stem cell biology, and there is now accumulating evidence demonstrating the effects of PEDF in a variety of stem cells, mainly in supporting stem cell survival and maintaining multipotency.
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spelling pubmed-33628742012-06-06 The Emerging Role of PEDF in Stem Cell Biology Elahy, Mina Baindur-Hudson, Swati Dass, Crispin R. J Biomed Biotechnol Review Article Encoded by a single gene, PEDF is a 50 kDa glycoprotein that is highly conserved and is widely expressed among many tissues. Most secreted PEDF deposits within the extracellular matrix, with cell-type-specific functions. While traditionally PEDF is known as a strong antiangiogenic factor, more recently, as this paper highlights, PEDF has been linked with stem cell biology, and there is now accumulating evidence demonstrating the effects of PEDF in a variety of stem cells, mainly in supporting stem cell survival and maintaining multipotency. Hindawi Publishing Corporation 2012 2012-05-17 /pmc/articles/PMC3362874/ /pubmed/22675247 http://dx.doi.org/10.1155/2012/239091 Text en Copyright © 2012 Mina Elahy et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Elahy, Mina
Baindur-Hudson, Swati
Dass, Crispin R.
The Emerging Role of PEDF in Stem Cell Biology
title The Emerging Role of PEDF in Stem Cell Biology
title_full The Emerging Role of PEDF in Stem Cell Biology
title_fullStr The Emerging Role of PEDF in Stem Cell Biology
title_full_unstemmed The Emerging Role of PEDF in Stem Cell Biology
title_short The Emerging Role of PEDF in Stem Cell Biology
title_sort emerging role of pedf in stem cell biology
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3362874/
https://www.ncbi.nlm.nih.gov/pubmed/22675247
http://dx.doi.org/10.1155/2012/239091
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