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Oral Lichen Planus as a Preneoplastic Inflammatory Model
Oral lichen planus (OLP) is a chronic oral inflammatory disease of unknown etiology. According to reports, 1-2% of OLP patients develop oral squamous cell carcinoma (OSCC) in the long run. While World Health Organization (WHO) classifies OLP as “a potentially malignant disorder,” it is still a matte...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3362930/ https://www.ncbi.nlm.nih.gov/pubmed/22675259 http://dx.doi.org/10.1155/2012/759626 |
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author | Georgakopoulou, Eleni A. Achtari, Marina D. Achtaris, Michael Foukas, Periklis G. Kotsinas, Athanassios |
author_facet | Georgakopoulou, Eleni A. Achtari, Marina D. Achtaris, Michael Foukas, Periklis G. Kotsinas, Athanassios |
author_sort | Georgakopoulou, Eleni A. |
collection | PubMed |
description | Oral lichen planus (OLP) is a chronic oral inflammatory disease of unknown etiology. According to reports, 1-2% of OLP patients develop oral squamous cell carcinoma (OSCC) in the long run. While World Health Organization (WHO) classifies OLP as “a potentially malignant disorder,” it is still a matter of debate which mechanisms drive OLP to such a condition. The current hypothesis connecting OLP and OSCC is that chronic inflammation results in crucial DNA damage which over time results in cancer development. Initial studies investigating the OLP and OSCC link were mainly retrospective clinical studies. Over the past years, several amount of information has accumulated, mainly from molecular studies on the OLP malignant potential. This article is a critical review of whether OLP has a malignant potential and, therefore, represents a model of preneoplastic inflammation. |
format | Online Article Text |
id | pubmed-3362930 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-33629302012-06-06 Oral Lichen Planus as a Preneoplastic Inflammatory Model Georgakopoulou, Eleni A. Achtari, Marina D. Achtaris, Michael Foukas, Periklis G. Kotsinas, Athanassios J Biomed Biotechnol Review Article Oral lichen planus (OLP) is a chronic oral inflammatory disease of unknown etiology. According to reports, 1-2% of OLP patients develop oral squamous cell carcinoma (OSCC) in the long run. While World Health Organization (WHO) classifies OLP as “a potentially malignant disorder,” it is still a matter of debate which mechanisms drive OLP to such a condition. The current hypothesis connecting OLP and OSCC is that chronic inflammation results in crucial DNA damage which over time results in cancer development. Initial studies investigating the OLP and OSCC link were mainly retrospective clinical studies. Over the past years, several amount of information has accumulated, mainly from molecular studies on the OLP malignant potential. This article is a critical review of whether OLP has a malignant potential and, therefore, represents a model of preneoplastic inflammation. Hindawi Publishing Corporation 2012 2012-05-17 /pmc/articles/PMC3362930/ /pubmed/22675259 http://dx.doi.org/10.1155/2012/759626 Text en Copyright © 2012 Eleni A. Georgakopoulou et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Georgakopoulou, Eleni A. Achtari, Marina D. Achtaris, Michael Foukas, Periklis G. Kotsinas, Athanassios Oral Lichen Planus as a Preneoplastic Inflammatory Model |
title | Oral Lichen Planus as a Preneoplastic Inflammatory Model |
title_full | Oral Lichen Planus as a Preneoplastic Inflammatory Model |
title_fullStr | Oral Lichen Planus as a Preneoplastic Inflammatory Model |
title_full_unstemmed | Oral Lichen Planus as a Preneoplastic Inflammatory Model |
title_short | Oral Lichen Planus as a Preneoplastic Inflammatory Model |
title_sort | oral lichen planus as a preneoplastic inflammatory model |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3362930/ https://www.ncbi.nlm.nih.gov/pubmed/22675259 http://dx.doi.org/10.1155/2012/759626 |
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