The Current Knowledge of the Role of PPAR in Hepatic Ischemia-Reperfusion Injury

Strategies to improve the viability of steatotic livers could reduce the risk of dysfunction after surgery and increase the number of organs suitable for transplantation. Peroxisome proliferator-activated receptors (PPARs) are major regulators of lipid metabolism and inflammation. In this paper, we...

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Detalles Bibliográficos
Autores principales: Elias-Miró, M., Jiménez-Castro, M. B., Mendes-Braz, M., Casillas-Ramírez, A., Peralta, C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3363006/
https://www.ncbi.nlm.nih.gov/pubmed/22675337
http://dx.doi.org/10.1155/2012/802384
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author Elias-Miró, M.
Jiménez-Castro, M. B.
Mendes-Braz, M.
Casillas-Ramírez, A.
Peralta, C.
author_facet Elias-Miró, M.
Jiménez-Castro, M. B.
Mendes-Braz, M.
Casillas-Ramírez, A.
Peralta, C.
author_sort Elias-Miró, M.
collection PubMed
description Strategies to improve the viability of steatotic livers could reduce the risk of dysfunction after surgery and increase the number of organs suitable for transplantation. Peroxisome proliferator-activated receptors (PPARs) are major regulators of lipid metabolism and inflammation. In this paper, we review the PPAR signaling pathways and present some of their lesser-known functions in liver regeneration. Potential therapies based on PPAR regulation will be discussed. The data suggest that further investigations are required to elucidate whether PPAR could be a potential therapeutic target in liver surgery and to determine the most effective therapies that selectively regulate PPAR with minor side effects.
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spelling pubmed-33630062012-06-06 The Current Knowledge of the Role of PPAR in Hepatic Ischemia-Reperfusion Injury Elias-Miró, M. Jiménez-Castro, M. B. Mendes-Braz, M. Casillas-Ramírez, A. Peralta, C. PPAR Res Review Article Strategies to improve the viability of steatotic livers could reduce the risk of dysfunction after surgery and increase the number of organs suitable for transplantation. Peroxisome proliferator-activated receptors (PPARs) are major regulators of lipid metabolism and inflammation. In this paper, we review the PPAR signaling pathways and present some of their lesser-known functions in liver regeneration. Potential therapies based on PPAR regulation will be discussed. The data suggest that further investigations are required to elucidate whether PPAR could be a potential therapeutic target in liver surgery and to determine the most effective therapies that selectively regulate PPAR with minor side effects. Hindawi Publishing Corporation 2012 2012-05-16 /pmc/articles/PMC3363006/ /pubmed/22675337 http://dx.doi.org/10.1155/2012/802384 Text en Copyright © 2012 M. Elias-Miró et al. https://creativecommons.org/licenses/by/3.0/ This is an open access paper distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Elias-Miró, M.
Jiménez-Castro, M. B.
Mendes-Braz, M.
Casillas-Ramírez, A.
Peralta, C.
The Current Knowledge of the Role of PPAR in Hepatic Ischemia-Reperfusion Injury
title The Current Knowledge of the Role of PPAR in Hepatic Ischemia-Reperfusion Injury
title_full The Current Knowledge of the Role of PPAR in Hepatic Ischemia-Reperfusion Injury
title_fullStr The Current Knowledge of the Role of PPAR in Hepatic Ischemia-Reperfusion Injury
title_full_unstemmed The Current Knowledge of the Role of PPAR in Hepatic Ischemia-Reperfusion Injury
title_short The Current Knowledge of the Role of PPAR in Hepatic Ischemia-Reperfusion Injury
title_sort current knowledge of the role of ppar in hepatic ischemia-reperfusion injury
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3363006/
https://www.ncbi.nlm.nih.gov/pubmed/22675337
http://dx.doi.org/10.1155/2012/802384
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