Safety of Mesenchymal Stem Cells for Clinical Application

Mesenchymal stem cells (MSCs) hold great promise as therapeutic agents in regenerative medicine and autoimmune diseases, based on their differentiation abilities and immunosuppressive properties. However, the therapeutic applications raise a series of questions about the safety of culture-expanded M...

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Detalles Bibliográficos
Autores principales: Wang, Youwei, Han, Zhi-bo, Song, Yong-ping, Han, Zhong Chao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3363282/
https://www.ncbi.nlm.nih.gov/pubmed/22685475
http://dx.doi.org/10.1155/2012/652034
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author Wang, Youwei
Han, Zhi-bo
Song, Yong-ping
Han, Zhong Chao
author_facet Wang, Youwei
Han, Zhi-bo
Song, Yong-ping
Han, Zhong Chao
author_sort Wang, Youwei
collection PubMed
description Mesenchymal stem cells (MSCs) hold great promise as therapeutic agents in regenerative medicine and autoimmune diseases, based on their differentiation abilities and immunosuppressive properties. However, the therapeutic applications raise a series of questions about the safety of culture-expanded MSCs for human use. This paper summarized recent findings about safety issues of MSCs, in particular their genetic stability in long-term in vitro expansion, their cryopreservation, banking, and the role of serum in the preparation of MSCs.
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spelling pubmed-33632822012-06-08 Safety of Mesenchymal Stem Cells for Clinical Application Wang, Youwei Han, Zhi-bo Song, Yong-ping Han, Zhong Chao Stem Cells Int Review Article Mesenchymal stem cells (MSCs) hold great promise as therapeutic agents in regenerative medicine and autoimmune diseases, based on their differentiation abilities and immunosuppressive properties. However, the therapeutic applications raise a series of questions about the safety of culture-expanded MSCs for human use. This paper summarized recent findings about safety issues of MSCs, in particular their genetic stability in long-term in vitro expansion, their cryopreservation, banking, and the role of serum in the preparation of MSCs. Hindawi Publishing Corporation 2012 2012-05-16 /pmc/articles/PMC3363282/ /pubmed/22685475 http://dx.doi.org/10.1155/2012/652034 Text en Copyright © 2012 Youwei Wang et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Wang, Youwei
Han, Zhi-bo
Song, Yong-ping
Han, Zhong Chao
Safety of Mesenchymal Stem Cells for Clinical Application
title Safety of Mesenchymal Stem Cells for Clinical Application
title_full Safety of Mesenchymal Stem Cells for Clinical Application
title_fullStr Safety of Mesenchymal Stem Cells for Clinical Application
title_full_unstemmed Safety of Mesenchymal Stem Cells for Clinical Application
title_short Safety of Mesenchymal Stem Cells for Clinical Application
title_sort safety of mesenchymal stem cells for clinical application
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3363282/
https://www.ncbi.nlm.nih.gov/pubmed/22685475
http://dx.doi.org/10.1155/2012/652034
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