Successful salvage therapy of Fusarium endophthalmitis secondary to keratitis: an interventional case series

PURPOSE: To describe a combination of treatment modalities used for the successful eradication of Fusarium endophthalmitis. DESIGN: Interventional case series. PARTICIPANTS: Three consecutive patients with keratitis-associated Fusarium endophthalmitis. METHODS: After failure of traditional management options, a combination of intravitreal and long-term, high-dose systemic voriconazole, topical antifungal medications, and surgical intervention, with penetrating keratoplasty, lensectomy, and endoscopic-guided pars plana vitrectomy, was administered to each patient. RESULTS: All three cases achieved full resolution of the infection, with a final Snellen visual acuity score of 20/50 to 20/70. CONCLUSIONS: An aggressive combination of therapeutic modalities, including the removal of subiris abscesses, might be needed for the successful resolution of Fusarium endophthalmitis.