Statistical colocalization of monocyte gene expression and genetic risk variants for type 1 diabetes

One mechanism by which disease-associated DNA variation can alter disease risk is altering gene expression. However, linkage disequilibrium (LD) between variants, mostly single-nucleotide polymorphisms (SNPs), means it is not sufficient to show that a particular variant associates with both disease...

Descripción completa

Detalles Bibliográficos
Autores principales: Wallace, Chris, Rotival, Maxime, Cooper, Jason D., Rice, Catherine M., Yang, Jennie H.M., McNeill, Mhairi, Smyth, Deborah J., Niblett, David, Cambien, François, Tiret, Laurence, Todd, John A., Clayton, David G., Blankenberg, Stefan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2012
Materias:
Association Studies Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3363338/
https://www.ncbi.nlm.nih.gov/pubmed/22403184
http://dx.doi.org/10.1093/hmg/dds098

Ejemplares similares

Ejemplares similares