Cargando…
Commonly Used Severity Scores Are Not Good Predictors of Mortality in Sepsis from Severe Leptospirosis: A Series of Ten Patients
Introduction. Severe leptospirosis, also known as Weil's disease, can cause multiorgan failure with high mortality. Scoring systems for disease severity have not been validated for leptospirosis, and there is no documented method to predict mortality. Methods. This is a case series on 10 patien...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2012
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3363413/ https://www.ncbi.nlm.nih.gov/pubmed/22675620 http://dx.doi.org/10.1155/2012/532376 |
_version_ | 1782234345115746304 |
---|---|
author | Velissaris, Dimitrios Karanikolas, Menelaos Flaris, Nikolaos Fligou, Fotini Marangos, Markos Filos, Kriton S. |
author_facet | Velissaris, Dimitrios Karanikolas, Menelaos Flaris, Nikolaos Fligou, Fotini Marangos, Markos Filos, Kriton S. |
author_sort | Velissaris, Dimitrios |
collection | PubMed |
description | Introduction. Severe leptospirosis, also known as Weil's disease, can cause multiorgan failure with high mortality. Scoring systems for disease severity have not been validated for leptospirosis, and there is no documented method to predict mortality. Methods. This is a case series on 10 patients admitted to ICU for multiorgan failure from severe leptospirosis. Data were collected retrospectively, with approval from the Institution Ethics Committee. Results. Ten patients with severe leptospirosis were admitted in the Patras University Hospital ICU in a four-year period. Although, based on SOFA scores, predicted mortality was over 80%, seven of 10 patients survived and were discharged from the hospital in good condition. There was no association between SAPS II or SOFA scores and mortality, but survivors had significantly lower APACHE II scores compared to nonsurvivors. Conclusion. Commonly used severity scores do not seem to be useful in predicting mortality in severe leptospirosis. Early ICU admission and resuscitation based on a goal-directed therapy protocol are recommended and may reduce mortality. However, this study is limited by retrospective data collection and small sample size. Data from large prospective studies are needed to validate our findings. |
format | Online Article Text |
id | pubmed-3363413 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-33634132012-06-06 Commonly Used Severity Scores Are Not Good Predictors of Mortality in Sepsis from Severe Leptospirosis: A Series of Ten Patients Velissaris, Dimitrios Karanikolas, Menelaos Flaris, Nikolaos Fligou, Fotini Marangos, Markos Filos, Kriton S. Crit Care Res Pract Clinical Study Introduction. Severe leptospirosis, also known as Weil's disease, can cause multiorgan failure with high mortality. Scoring systems for disease severity have not been validated for leptospirosis, and there is no documented method to predict mortality. Methods. This is a case series on 10 patients admitted to ICU for multiorgan failure from severe leptospirosis. Data were collected retrospectively, with approval from the Institution Ethics Committee. Results. Ten patients with severe leptospirosis were admitted in the Patras University Hospital ICU in a four-year period. Although, based on SOFA scores, predicted mortality was over 80%, seven of 10 patients survived and were discharged from the hospital in good condition. There was no association between SAPS II or SOFA scores and mortality, but survivors had significantly lower APACHE II scores compared to nonsurvivors. Conclusion. Commonly used severity scores do not seem to be useful in predicting mortality in severe leptospirosis. Early ICU admission and resuscitation based on a goal-directed therapy protocol are recommended and may reduce mortality. However, this study is limited by retrospective data collection and small sample size. Data from large prospective studies are needed to validate our findings. Hindawi Publishing Corporation 2012 2012-05-21 /pmc/articles/PMC3363413/ /pubmed/22675620 http://dx.doi.org/10.1155/2012/532376 Text en Copyright © 2012 Dimitrios Velissaris et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Clinical Study Velissaris, Dimitrios Karanikolas, Menelaos Flaris, Nikolaos Fligou, Fotini Marangos, Markos Filos, Kriton S. Commonly Used Severity Scores Are Not Good Predictors of Mortality in Sepsis from Severe Leptospirosis: A Series of Ten Patients |
title | Commonly Used Severity Scores Are Not Good Predictors of Mortality in Sepsis from Severe Leptospirosis: A Series of Ten Patients |
title_full | Commonly Used Severity Scores Are Not Good Predictors of Mortality in Sepsis from Severe Leptospirosis: A Series of Ten Patients |
title_fullStr | Commonly Used Severity Scores Are Not Good Predictors of Mortality in Sepsis from Severe Leptospirosis: A Series of Ten Patients |
title_full_unstemmed | Commonly Used Severity Scores Are Not Good Predictors of Mortality in Sepsis from Severe Leptospirosis: A Series of Ten Patients |
title_short | Commonly Used Severity Scores Are Not Good Predictors of Mortality in Sepsis from Severe Leptospirosis: A Series of Ten Patients |
title_sort | commonly used severity scores are not good predictors of mortality in sepsis from severe leptospirosis: a series of ten patients |
topic | Clinical Study |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3363413/ https://www.ncbi.nlm.nih.gov/pubmed/22675620 http://dx.doi.org/10.1155/2012/532376 |
work_keys_str_mv | AT velissarisdimitrios commonlyusedseverityscoresarenotgoodpredictorsofmortalityinsepsisfromsevereleptospirosisaseriesoftenpatients AT karanikolasmenelaos commonlyusedseverityscoresarenotgoodpredictorsofmortalityinsepsisfromsevereleptospirosisaseriesoftenpatients AT flarisnikolaos commonlyusedseverityscoresarenotgoodpredictorsofmortalityinsepsisfromsevereleptospirosisaseriesoftenpatients AT fligoufotini commonlyusedseverityscoresarenotgoodpredictorsofmortalityinsepsisfromsevereleptospirosisaseriesoftenpatients AT marangosmarkos commonlyusedseverityscoresarenotgoodpredictorsofmortalityinsepsisfromsevereleptospirosisaseriesoftenpatients AT filoskritons commonlyusedseverityscoresarenotgoodpredictorsofmortalityinsepsisfromsevereleptospirosisaseriesoftenpatients |