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Dysbiosis in the Pathogenesis of Pediatric Inflammatory Bowel Diseases
Inflammatory bowel diseases (IBDs) are chronic inflammatory conditions of the gastrointestinal tract that occur in genetically susceptible individuals. Crohn's disease (CD) and ulcerative colitis (UC) are two major types of IBD. In about 20–25% of patients, disease onset is during childhood and...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3363416/ https://www.ncbi.nlm.nih.gov/pubmed/22685684 http://dx.doi.org/10.1155/2012/687143 |
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author | Comito, Donatella Romano, Claudio |
author_facet | Comito, Donatella Romano, Claudio |
author_sort | Comito, Donatella |
collection | PubMed |
description | Inflammatory bowel diseases (IBDs) are chronic inflammatory conditions of the gastrointestinal tract that occur in genetically susceptible individuals. Crohn's disease (CD) and ulcerative colitis (UC) are two major types of IBD. In about 20–25% of patients, disease onset is during childhood and pediatric IBD can be considered the best model for studying immunopathogentic mechanisms. The fundamentals of IBD pathogenesis are considered a defective innate immunity and bacterial killing with overaggressive adaptive immune response. A condition of “dysbiosis”, with alterations of the gut microbial composition, is regarded as the basis of IBD pathogenesis. The human gastrointestinal (GI) microbial population is a complex, dynamic ecosystem and consists of up to one thousand different bacterial species. In healthy individuals, intestinal microbiota have a symbiotic relationship with the host organism and carry out important metabolic, “barrier,” and immune functions. Microbial dysbiosis in IBD with lack of beneficial bacteria, together with genetic predisposition, is the most relevant conditions in the pathogenesis of the pediatric IBD. |
format | Online Article Text |
id | pubmed-3363416 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-33634162012-06-08 Dysbiosis in the Pathogenesis of Pediatric Inflammatory Bowel Diseases Comito, Donatella Romano, Claudio Int J Inflam Review Article Inflammatory bowel diseases (IBDs) are chronic inflammatory conditions of the gastrointestinal tract that occur in genetically susceptible individuals. Crohn's disease (CD) and ulcerative colitis (UC) are two major types of IBD. In about 20–25% of patients, disease onset is during childhood and pediatric IBD can be considered the best model for studying immunopathogentic mechanisms. The fundamentals of IBD pathogenesis are considered a defective innate immunity and bacterial killing with overaggressive adaptive immune response. A condition of “dysbiosis”, with alterations of the gut microbial composition, is regarded as the basis of IBD pathogenesis. The human gastrointestinal (GI) microbial population is a complex, dynamic ecosystem and consists of up to one thousand different bacterial species. In healthy individuals, intestinal microbiota have a symbiotic relationship with the host organism and carry out important metabolic, “barrier,” and immune functions. Microbial dysbiosis in IBD with lack of beneficial bacteria, together with genetic predisposition, is the most relevant conditions in the pathogenesis of the pediatric IBD. Hindawi Publishing Corporation 2012 2012-05-20 /pmc/articles/PMC3363416/ /pubmed/22685684 http://dx.doi.org/10.1155/2012/687143 Text en Copyright © 2012 D. Comito and C. Romano. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Comito, Donatella Romano, Claudio Dysbiosis in the Pathogenesis of Pediatric Inflammatory Bowel Diseases |
title | Dysbiosis in the Pathogenesis of Pediatric Inflammatory Bowel Diseases |
title_full | Dysbiosis in the Pathogenesis of Pediatric Inflammatory Bowel Diseases |
title_fullStr | Dysbiosis in the Pathogenesis of Pediatric Inflammatory Bowel Diseases |
title_full_unstemmed | Dysbiosis in the Pathogenesis of Pediatric Inflammatory Bowel Diseases |
title_short | Dysbiosis in the Pathogenesis of Pediatric Inflammatory Bowel Diseases |
title_sort | dysbiosis in the pathogenesis of pediatric inflammatory bowel diseases |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3363416/ https://www.ncbi.nlm.nih.gov/pubmed/22685684 http://dx.doi.org/10.1155/2012/687143 |
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