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Diverse Functions of Pulmonary Collectins in Host Defense of the Lung

Pulmonary surfactant is a mixture of lipids and proteins that covers alveolar surfaces and keeps alveoli from collapsing. Four specific proteins have been identified in surfactant. Among them, two C-type lectins, surfactant proteins A and D (SP-A and SP-D), are known to be implicated in host defense...

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Detalles Bibliográficos
Autores principales: Ariki, Shigeru, Nishitani, Chiaki, Kuroki, Yoshio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3364019/
https://www.ncbi.nlm.nih.gov/pubmed/22675254
http://dx.doi.org/10.1155/2012/532071
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author Ariki, Shigeru
Nishitani, Chiaki
Kuroki, Yoshio
author_facet Ariki, Shigeru
Nishitani, Chiaki
Kuroki, Yoshio
author_sort Ariki, Shigeru
collection PubMed
description Pulmonary surfactant is a mixture of lipids and proteins that covers alveolar surfaces and keeps alveoli from collapsing. Four specific proteins have been identified in surfactant. Among them, two C-type lectins, surfactant proteins A and D (SP-A and SP-D), are known to be implicated in host defense and regulation of inflammatory responses of the lung. These host defense lectins are structurally characterized by N-terminal collagen-like domains and lectin domains and are called pulmonary collectins. They prevent dissemination of infectious microbes by their biological activities including agglutination and growth inhibition. They also promote clearance of microbes by enhancing phagocytosis in macrophages. In addition, they interact with the other pattern-recognition molecules, including Toll-like receptors (TLRs) and TLR-associated molecules, CD14 and MD-2, and regulate inflammatory responses. Furthermore, recent studies have demonstrated that these collectins modulate functions of neutrophil-derived innate immune molecules by interacting with them. These findings indicate that pulmonary collectins play critical roles in host defense of the lung.
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spelling pubmed-33640192012-06-06 Diverse Functions of Pulmonary Collectins in Host Defense of the Lung Ariki, Shigeru Nishitani, Chiaki Kuroki, Yoshio J Biomed Biotechnol Review Article Pulmonary surfactant is a mixture of lipids and proteins that covers alveolar surfaces and keeps alveoli from collapsing. Four specific proteins have been identified in surfactant. Among them, two C-type lectins, surfactant proteins A and D (SP-A and SP-D), are known to be implicated in host defense and regulation of inflammatory responses of the lung. These host defense lectins are structurally characterized by N-terminal collagen-like domains and lectin domains and are called pulmonary collectins. They prevent dissemination of infectious microbes by their biological activities including agglutination and growth inhibition. They also promote clearance of microbes by enhancing phagocytosis in macrophages. In addition, they interact with the other pattern-recognition molecules, including Toll-like receptors (TLRs) and TLR-associated molecules, CD14 and MD-2, and regulate inflammatory responses. Furthermore, recent studies have demonstrated that these collectins modulate functions of neutrophil-derived innate immune molecules by interacting with them. These findings indicate that pulmonary collectins play critical roles in host defense of the lung. Hindawi Publishing Corporation 2012 2012-05-20 /pmc/articles/PMC3364019/ /pubmed/22675254 http://dx.doi.org/10.1155/2012/532071 Text en Copyright © 2012 Shigeru Ariki et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Ariki, Shigeru
Nishitani, Chiaki
Kuroki, Yoshio
Diverse Functions of Pulmonary Collectins in Host Defense of the Lung
title Diverse Functions of Pulmonary Collectins in Host Defense of the Lung
title_full Diverse Functions of Pulmonary Collectins in Host Defense of the Lung
title_fullStr Diverse Functions of Pulmonary Collectins in Host Defense of the Lung
title_full_unstemmed Diverse Functions of Pulmonary Collectins in Host Defense of the Lung
title_short Diverse Functions of Pulmonary Collectins in Host Defense of the Lung
title_sort diverse functions of pulmonary collectins in host defense of the lung
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3364019/
https://www.ncbi.nlm.nih.gov/pubmed/22675254
http://dx.doi.org/10.1155/2012/532071
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