Regulation of Wnt signaling by the tumor suppressor adenomatous polyposis coli does not require the ability to enter the nucleus or a particular cytoplasmic localization

Wnt signaling plays key roles in development and disease. The tumor suppressor adenomatous polyposis coli (APC) is an essential negative regulator of Wnt signaling. Its best-characterized role is as part of the destruction complex, targeting the Wnt effector β-catenin (βcat) for phosphorylation and...

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Detalles Bibliográficos
Autores principales: Roberts, David M., Pronobis, Mira I., Poulton, John S., Kane, Eric G., Peifer, Mark
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2012
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3364170/
https://www.ncbi.nlm.nih.gov/pubmed/22513088
http://dx.doi.org/10.1091/mbc.E11-11-0965

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