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Sarcopenia Predicts Early Dose-Limiting Toxicities and Pharmacokinetics of Sorafenib in Patients with Hepatocellular Carcinoma

BACKGROUND: Sorafenib induces frequent dose limiting toxicities (DLT) in patients with advanced hepatocellular carcinoma (HCC). Sarcopenia has been associated with poor performance status and shortened survival in cancer patients. PATIENTS AND METHODS: The characteristics of Child Pugh A cirrhotic p...

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Detalles Bibliográficos
Autores principales:	Mir, Olivier, Coriat, Romain, Blanchet, Benoit, Durand, Jean-Philippe, Boudou-Rouquette, Pascaline, Michels, Judith, Ropert, Stanislas, Vidal, Michel, Pol, Stanislas, Chaussade, Stanislas, Goldwasser, François
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3364283/ https://www.ncbi.nlm.nih.gov/pubmed/22666367 http://dx.doi.org/10.1371/journal.pone.0037563

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