Prenatal Famine and Genetic Variation Are Independently and Additively Associated with DNA Methylation at Regulatory Loci within IGF2/H19

Both the early environment and genetic variation may affect DNA methylation, which is one of the major molecular marks of the epigenome. The combined effect of these factors on a well-defined locus has not been studied to date. We evaluated the association of periconceptional exposure to the Dutch F...

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Detalles Bibliográficos
Autores principales: Tobi, Elmar W., Slagboom, P. Eline, van Dongen, Jenny, Kremer, Dennis, Stein, Aryeh D., Putter, Hein, Heijmans, Bastiaan T., Lumey, L. H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3364289/
https://www.ncbi.nlm.nih.gov/pubmed/22666415
http://dx.doi.org/10.1371/journal.pone.0037933

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3364289/
https://www.ncbi.nlm.nih.gov/pubmed/22666415
http://dx.doi.org/10.1371/journal.pone.0037933

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