Lack of association of -607 C/A and -137 G/C polymorphisms in interleukin 18 gene with susceptibility to gout disease in Chinese Han male population

To identify association of IL18-607 C/A and -137 G/C polymorphism with susceptibility to gout in Chinese Han male population, We evaluate the genetic contribution of the IL18-607 C/A and -137 G/C polymorphism in 202 gout male patients and 493 gout-free control of Chinese Han population by allele-spe...

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Autores principales: Li, Changgui, Yuan, Ying, Wang, Xinfeng, Han, Lin, Chu, Nan, Wang, Hui, Liu, Shiguo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer-Verlag 2011
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3364418/
https://www.ncbi.nlm.nih.gov/pubmed/21487696
http://dx.doi.org/10.1007/s00296-011-1936-5
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author Li, Changgui
Yuan, Ying
Wang, Xinfeng
Han, Lin
Chu, Nan
Wang, Hui
Liu, Shiguo
author_facet Li, Changgui
Yuan, Ying
Wang, Xinfeng
Han, Lin
Chu, Nan
Wang, Hui
Liu, Shiguo
author_sort Li, Changgui
collection PubMed
description To identify association of IL18-607 C/A and -137 G/C polymorphism with susceptibility to gout in Chinese Han male population, We evaluate the genetic contribution of the IL18-607 C/A and -137 G/C polymorphism in 202 gout male patients and 493 gout-free control of Chinese Han population by allele-specific polymerase chain reaction assay. Our results reveal no significant association between the polymorphisms -607C/A and -137G/C in IL18 with gout. Our study might suggest that -607 C/A and -137 G/C polymorphisms in the promoter of IL18 are not associated with susceptibility to gout and thus do not play a major role in the development of gout in the Chinese Han male population.
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spelling pubmed-33644182012-06-13 Lack of association of -607 C/A and -137 G/C polymorphisms in interleukin 18 gene with susceptibility to gout disease in Chinese Han male population Li, Changgui Yuan, Ying Wang, Xinfeng Han, Lin Chu, Nan Wang, Hui Liu, Shiguo Rheumatol Int Short Communication To identify association of IL18-607 C/A and -137 G/C polymorphism with susceptibility to gout in Chinese Han male population, We evaluate the genetic contribution of the IL18-607 C/A and -137 G/C polymorphism in 202 gout male patients and 493 gout-free control of Chinese Han population by allele-specific polymerase chain reaction assay. Our results reveal no significant association between the polymorphisms -607C/A and -137G/C in IL18 with gout. Our study might suggest that -607 C/A and -137 G/C polymorphisms in the promoter of IL18 are not associated with susceptibility to gout and thus do not play a major role in the development of gout in the Chinese Han male population. Springer-Verlag 2011-04-13 2012 /pmc/articles/PMC3364418/ /pubmed/21487696 http://dx.doi.org/10.1007/s00296-011-1936-5 Text en © The Author(s) 2011 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.
spellingShingle Short Communication
Li, Changgui
Yuan, Ying
Wang, Xinfeng
Han, Lin
Chu, Nan
Wang, Hui
Liu, Shiguo
Lack of association of -607 C/A and -137 G/C polymorphisms in interleukin 18 gene with susceptibility to gout disease in Chinese Han male population
title Lack of association of -607 C/A and -137 G/C polymorphisms in interleukin 18 gene with susceptibility to gout disease in Chinese Han male population
title_full Lack of association of -607 C/A and -137 G/C polymorphisms in interleukin 18 gene with susceptibility to gout disease in Chinese Han male population
title_fullStr Lack of association of -607 C/A and -137 G/C polymorphisms in interleukin 18 gene with susceptibility to gout disease in Chinese Han male population
title_full_unstemmed Lack of association of -607 C/A and -137 G/C polymorphisms in interleukin 18 gene with susceptibility to gout disease in Chinese Han male population
title_short Lack of association of -607 C/A and -137 G/C polymorphisms in interleukin 18 gene with susceptibility to gout disease in Chinese Han male population
title_sort lack of association of -607 c/a and -137 g/c polymorphisms in interleukin 18 gene with susceptibility to gout disease in chinese han male population
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3364418/
https://www.ncbi.nlm.nih.gov/pubmed/21487696
http://dx.doi.org/10.1007/s00296-011-1936-5
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