Genomics of Acute Myeloid Leukemia: The Next Generation

Acute myeloid leukemia (AML) is, as other types of cancer, a genetic disorder of somatic cells. The detection of somatic molecular abnormalities that may cause and maintain AML is crucial for patient stratification. The development of mutation-specific therapeutic interventions will hopefully increa...

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Detalles Bibliográficos
Autores principales: Riva, Laura, Luzi, Lucilla, Pelicci, Pier Giuseppe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Research Foundation 2012
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3364462/
https://www.ncbi.nlm.nih.gov/pubmed/22666660
http://dx.doi.org/10.3389/fonc.2012.00040
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author Riva, Laura
Luzi, Lucilla
Pelicci, Pier Giuseppe
author_facet Riva, Laura
Luzi, Lucilla
Pelicci, Pier Giuseppe
author_sort Riva, Laura
collection PubMed
description Acute myeloid leukemia (AML) is, as other types of cancer, a genetic disorder of somatic cells. The detection of somatic molecular abnormalities that may cause and maintain AML is crucial for patient stratification. The development of mutation-specific therapeutic interventions will hopefully increase cure rates and improve patients’ quality of life. This review illustrates how next generation sequencing technologies are changing the study of cancer genomics of adult AML patients.
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spelling pubmed-33644622012-06-04 Genomics of Acute Myeloid Leukemia: The Next Generation Riva, Laura Luzi, Lucilla Pelicci, Pier Giuseppe Front Oncol Oncology Acute myeloid leukemia (AML) is, as other types of cancer, a genetic disorder of somatic cells. The detection of somatic molecular abnormalities that may cause and maintain AML is crucial for patient stratification. The development of mutation-specific therapeutic interventions will hopefully increase cure rates and improve patients’ quality of life. This review illustrates how next generation sequencing technologies are changing the study of cancer genomics of adult AML patients. Frontiers Research Foundation 2012-05-01 /pmc/articles/PMC3364462/ /pubmed/22666660 http://dx.doi.org/10.3389/fonc.2012.00040 Text en Copyright © 2012 Riva, Luzi and Pelicci. http://www.frontiersin.org/licenseagreement This is an open-access article distributed under the terms of the Creative Commons Attribution Non Commercial License, which permits non-commercial use, distribution, and reproduction in other forums, provided the original authors and source are credited.
spellingShingle Oncology
Riva, Laura
Luzi, Lucilla
Pelicci, Pier Giuseppe
Genomics of Acute Myeloid Leukemia: The Next Generation
title Genomics of Acute Myeloid Leukemia: The Next Generation
title_full Genomics of Acute Myeloid Leukemia: The Next Generation
title_fullStr Genomics of Acute Myeloid Leukemia: The Next Generation
title_full_unstemmed Genomics of Acute Myeloid Leukemia: The Next Generation
title_short Genomics of Acute Myeloid Leukemia: The Next Generation
title_sort genomics of acute myeloid leukemia: the next generation
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3364462/
https://www.ncbi.nlm.nih.gov/pubmed/22666660
http://dx.doi.org/10.3389/fonc.2012.00040
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