EMT and induction of miR-21 mediate metastasis development in Trp53-deficient tumours

Missense mutations in TP53 gene promote metastasis in human tumours. However, little is known about the complete loss of function of p53 in tumour metastasis. Here we show that squamous cell carcinomas generated by the specific ablation of Trp53 gene in mouse epidermis are highly metastatic. Biochem...

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Detalles Bibliográficos
Autores principales: Bornachea, Olga, Santos, Mirentxu, Martínez-Cruz, Ana Belén, García-Escudero, Ramón, Dueñas, Marta, Costa, Clotilde, Segrelles, Carmen, Lorz, Corina, Buitrago, Agueda, Saiz-Ladera, Cristina, Agirre, Xabier, Grande, Teresa, Paradela, Beatriz, Maraver, Antonio, Ariza, José M., Prosper, Felipe, Serrano, Manuel, Sánchez-Céspedes, Montse, Paramio, Jesús M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3364492/
https://www.ncbi.nlm.nih.gov/pubmed/22666537
http://dx.doi.org/10.1038/srep00434

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