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Mouse Models of Down Syndrome as a Tool to Unravel the Causes of Mental Disabilities

Down syndrome (DS) is the most common genetic cause of mental disability. Based on the homology of Hsa21 and the murine chromosomes Mmu16, Mmu17 and Mmu10, several mouse models of DS have been developed. The most commonly used model, the Ts65Dn mouse, has been widely used to investigate the neural m...

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Detalles Bibliográficos
Autores principales:	Rueda, Noemí, Flórez, Jesús, Martínez-Cué, Carmen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2012
Materias:	Review Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3364589/ https://www.ncbi.nlm.nih.gov/pubmed/22685678 http://dx.doi.org/10.1155/2012/584071

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