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Whole blood viscosity determination in diabetes management: perspective in practice

BACKGROUND: Antiplatelet and antioxidant nutritional therapies (ANT) are commonly used in diabetes management. Guidelines recommend identifying deficiencies of antioxidant vitamins and condition of no contraindication for nutritional and antiplatelet respectively. AIM: To determine whether the guide...

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Autores principales: Nwose, Ezekiel Uba, Butkowski, Eugene, Cann, Nathan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3364638/
https://www.ncbi.nlm.nih.gov/pubmed/22666680
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author Nwose, Ezekiel Uba
Butkowski, Eugene
Cann, Nathan
author_facet Nwose, Ezekiel Uba
Butkowski, Eugene
Cann, Nathan
author_sort Nwose, Ezekiel Uba
collection PubMed
description BACKGROUND: Antiplatelet and antioxidant nutritional therapies (ANT) are commonly used in diabetes management. Guidelines recommend identifying deficiencies of antioxidant vitamins and condition of no contraindication for nutritional and antiplatelet respectively. AIM: To determine whether the guidelines recommendations for diabetes patients to be assessed for (1) antioxidant vitamins’ deficiencies and/or (2) whole blood viscosity (WBV) as indication of no antiplatelet contraindication. MATERIALS AND METHOD: Laboratory records were audited. 10,342 de-identified glycaemic index (HbA1(c)) requests received in 2008 were sorted into three groups based on level of control. (1) Poor (n = 1962, HbA1(c) ≥ 8.1); (2) Good (n = 5616, HbA1(c) = 6.0 – 8.0) and (3) Excellent (n = 2764, HbA1(c) ≤ 5.9). All 57 cases with haematocrit and total protein results in the poor (n=30) and excellent (n=27) groups were selected for calculation and comparison of WBV levels. RESULTS: None of the two guidelines’ recommendations are being followed as no case was requested for any antioxidant vitamin or WBV. Assessments of the latter show that WBV is statistically significantly lower (p < 0.05) in the group with excellent glycaemic control compared to the group with poor glycaemic control. CONCLUSION: Aspirin is one of the therapies in diabetes management. Its effect is modulated by WBV. ANT is alternative to aspirin and influences WBV. For patients that have full blood count and plasma protein results, WBV can be extrapolated at no extra cost to the health system. There is a need to raise awareness for the recommended guidelines for laboratory monitoring to be followed.
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spelling pubmed-33646382012-06-04 Whole blood viscosity determination in diabetes management: perspective in practice Nwose, Ezekiel Uba Butkowski, Eugene Cann, Nathan N Am J Med Sci Original Article BACKGROUND: Antiplatelet and antioxidant nutritional therapies (ANT) are commonly used in diabetes management. Guidelines recommend identifying deficiencies of antioxidant vitamins and condition of no contraindication for nutritional and antiplatelet respectively. AIM: To determine whether the guidelines recommendations for diabetes patients to be assessed for (1) antioxidant vitamins’ deficiencies and/or (2) whole blood viscosity (WBV) as indication of no antiplatelet contraindication. MATERIALS AND METHOD: Laboratory records were audited. 10,342 de-identified glycaemic index (HbA1(c)) requests received in 2008 were sorted into three groups based on level of control. (1) Poor (n = 1962, HbA1(c) ≥ 8.1); (2) Good (n = 5616, HbA1(c) = 6.0 – 8.0) and (3) Excellent (n = 2764, HbA1(c) ≤ 5.9). All 57 cases with haematocrit and total protein results in the poor (n=30) and excellent (n=27) groups were selected for calculation and comparison of WBV levels. RESULTS: None of the two guidelines’ recommendations are being followed as no case was requested for any antioxidant vitamin or WBV. Assessments of the latter show that WBV is statistically significantly lower (p < 0.05) in the group with excellent glycaemic control compared to the group with poor glycaemic control. CONCLUSION: Aspirin is one of the therapies in diabetes management. Its effect is modulated by WBV. ANT is alternative to aspirin and influences WBV. For patients that have full blood count and plasma protein results, WBV can be extrapolated at no extra cost to the health system. There is a need to raise awareness for the recommended guidelines for laboratory monitoring to be followed. Medknow Publications & Media Pvt Ltd 2009-08 /pmc/articles/PMC3364638/ /pubmed/22666680 Text en Copyright: © North American Journal of Medical Sciences http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Nwose, Ezekiel Uba
Butkowski, Eugene
Cann, Nathan
Whole blood viscosity determination in diabetes management: perspective in practice
title Whole blood viscosity determination in diabetes management: perspective in practice
title_full Whole blood viscosity determination in diabetes management: perspective in practice
title_fullStr Whole blood viscosity determination in diabetes management: perspective in practice
title_full_unstemmed Whole blood viscosity determination in diabetes management: perspective in practice
title_short Whole blood viscosity determination in diabetes management: perspective in practice
title_sort whole blood viscosity determination in diabetes management: perspective in practice
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3364638/
https://www.ncbi.nlm.nih.gov/pubmed/22666680
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