Cargando…

Breaking the HAC Barrier: Histone H3K9 acetyl/methyl balance regulates CENP-A assembly

The kinetochore is responsible for accurate chromosome segregation. However, the mechanism by which kinetochores assemble and are maintained remains unclear. Here we report that de novo CENP-A assembly and kinetochore formation on human centromeric alphoid DNA arrays is regulated by a histone H3K9 a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ohzeki, Jun-ichirou, Bergmann, Jan H, Kouprina, Natalay, Noskov, Vladimir N, Nakano, Megumi, Kimura, Hiroshi, Earnshaw, William C, Larionov, Vladimir, Masumoto, Hiroshi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	European Molecular Biology Organization 2012
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3364751/ https://www.ncbi.nlm.nih.gov/pubmed/22473132 http://dx.doi.org/10.1038/emboj.2012.82

Ejemplares similares

CENP-B creates alternative epigenetic chromatin states permissive for CENP-A or heterochromatin assembly
por: Otake, Koichiro, et al.
Publicado: (2020)

CENP-C and CENP-I are key connecting factors for kinetochore and CENP-A assembly
por: Shono, Nobuaki, et al.
Publicado: (2015)

Combination of CENP-B Box Positive and Negative Synthetic Alpha Satellite Repeats Improves De Novo Human Artificial Chromosome Formation
por: Okazaki, Koei, et al.
Publicado: (2022)

Generation of a conditionally self-eliminating HAC gene delivery vector through incorporation of a tTA(VP64) expression cassette
por: Kononenko, Artem V., et al.
Publicado: (2015)

Analysis of Complex DNA Rearrangements during Early Stages of HAC Formation
por: Pesenti, Elisa, et al.
Publicado: (2020)

A portable BRCA1-HAC (human artificial chromosome) module for analysis of BRCA1 tumor suppressor function
por: Kononenko, Artem V., et al.
Publicado: (2014)

Nap1 regulates proper CENP-B binding to nucleosomes
por: Tachiwana, Hiroaki, et al.
Publicado: (2013)

Human Artificial Chromosome with Regulated Centromere: A Tool for Genome and Cancer Studies
por: Kouprina, Natalay, et al.
Publicado: (2018)

CENP-B box is required for de novo centromere chromatin assembly on human alphoid DNA
por: Ohzeki, Jun-ichirou, et al.
Publicado: (2002)

Novel screen for anti-cancer drugs that elevate chromosome instability (CIN) using human artificial chromosome (HAC)
por: Kouprina, Natalay, et al.
Publicado: (2018)

Protecting a transgene expression from the HAC-based vector by different chromatin insulators
por: Lee, Nicholas CO, et al.
Publicado: (2013)

Development of a novel HAC-based “gain of signal” quantitative assay for measuring chromosome instability (CIN) in cancer cells
por: Kim, Jung-Hyun, et al.
Publicado: (2016)

Re-engineering an alphoid(tetO)-HAC-based vector to enable high-throughput analyses of gene function
por: Kononenko, Artem V., et al.
Publicado: (2013)

Stable complex formation of CENP-B with the CENP-A nucleosome
por: Fujita, Risa, et al.
Publicado: (2015)

KAT7/HBO1/MYST2 Regulates CENP-A Chromatin Assembly by Antagonizing Suv39h1-Mediated Centromere Inactivation
por: Ohzeki, Jun-ichirou, et al.
Publicado: (2016)

Epigenetic engineering reveals a balance between histone modifications and transcription in kinetochore maintenance
por: Molina, Oscar, et al.
Publicado: (2016)

Actively transcribed rDNA and distal junction (DJ) sequence are involved in association of NORs with nucleoli
por: Liskovykh, Mikhail, et al.
Publicado: (2023)

Rapid generation of long tandem DNA repeat arrays by homologous recombination in yeast to study their function in mammalian genomes
por: Noskov, Vladimir N, et al.
Publicado: (2011)

Generation of a Synthetic Human Chromosome with Two Centromeric Domains for Advanced Epigenetic Engineering Studies
por: Pesenti, Elisa, et al.
Publicado: (2018)

Rapid generation of long synthetic tandem repeats and its application for analysis in human artificial chromosome formation
por: Ebersole, Tom, et al.
Publicado: (2005)

Replication of alpha-satellite DNA arrays in endogenous human centromeric regions and in human artificial chromosome
por: Erliandri, Indri, et al.
Publicado: (2014)

Method to Assemble Genomic DNA Fragments or Genes on Human Artificial Chromosome with Regulated Kinetochore Using a Multi-Integrase System
por: Lee, Nicholas C. O., et al.
Publicado: (2017)

Epigenetic engineering shows H3K4me2 is required for HJURP targeting and CENP-A assembly on a synthetic human kinetochore
por: Bergmann, Jan H, et al.
Publicado: (2011)

Recent advances in chromosome engineering
por: Kouprina, Natalay, et al.
Publicado: (2015)

TAR Cloning: Perspectives for Functional Genomics, Biomedicine, and Biotechnology
por: Kouprina, Natalay, et al.
Publicado: (2019)

3D-CLEM Reveals that a Major Portion of Mitotic Chromosomes Is Not Chromatin
por: Booth, Daniel G., et al.
Publicado: (2016)

Terpyridine platinum compounds induce telomere dysfunction and chromosome instability in cancer cells
por: Petrov, Nikolai, et al.
Publicado: (2021)

Inactivation of a Human Kinetochore by Specific Targeting of Chromatin Modifiers
por: Nakano, Megumi, et al.
Publicado: (2008)

A general cloning system to selectively isolate any eukaryotic or prokaryotic genomic region in yeast
por: Noskov, Vladimir N, et al.
Publicado: (2003)

A new assay for measuring chromosome instability (CIN) and identification of drugs that elevate CIN in cancer cells
por: Lee, Hee-Sheung, et al.
Publicado: (2013)

Highly Selective, CRISPR/Cas9‐Mediated Isolation of Genes and Genomic Loci from Complex Genomes by TAR Cloning in Yeast
por: Kouprina, Natalay, et al.
Publicado: (2021)

Highly efficient CRISPR/Cas9-mediated TAR cloning of genes and chromosomal loci from complex genomes in yeast
por: Lee, Nicholas C.O., et al.
Publicado: (2015)

Moving toward a higher efficiency of microcell-mediated chromosome transfer
por: Liskovykh, Mikhail, et al.
Publicado: (2016)

Epigenetic engineering shows that a human centromere resists silencing mediated by H3K27me3/K9me3
por: Martins, Nuno M. C., et al.
Publicado: (2016)

Acetylation of histone H4 lysine 5 and 12 is required for CENP-A deposition into centromeres
por: Shang, Wei-Hao, et al.
Publicado: (2016)

Assembly of Multiple Full‐Size Genes or Genomic DNA Fragments on Human Artificial Chromosomes Using the Iterative Integration System
por: Lee, Nicholas C. O., et al.
Publicado: (2021)

Human Artificial Chromosome with a Conditional Centromere for Gene Delivery and Gene Expression
por: Iida, Yuichi, et al.
Publicado: (2010)

A novel assay to screen siRNA libraries identifies protein kinases required for chromosome transmission
por: Liskovykh, Mikhail, et al.
Publicado: (2019)

Analysis of the 9p21.3 sequence associated with coronary artery disease reveals a tendency for duplication in a CAD patient
por: Kouprina, Natalay, et al.
Publicado: (2018)

Histone H4 Lys 20 Monomethylation of the CENP-A Nucleosome Is Essential for Kinetochore Assembly
por: Hori, Tetsuya, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_rsnlvm24iigfdrk94h8mikb02n