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Stem cells and other innovative intra-articular therapies for osteoarthritis: what does the future hold?

Osteoarthritis (OA), the most common type of arthritis in the world, is associated with suffering due to pain, productivity loss, decreased mobility and quality of life. Systemic therapies available for OA are mostly symptom modifying and have potential gastrointestinal, renal, hepatic, and cardiac...

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Detalles Bibliográficos
Autor principal: Singh, Jasvinder A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3364907/
https://www.ncbi.nlm.nih.gov/pubmed/22551396
http://dx.doi.org/10.1186/1741-7015-10-44
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author Singh, Jasvinder A
author_facet Singh, Jasvinder A
author_sort Singh, Jasvinder A
collection PubMed
description Osteoarthritis (OA), the most common type of arthritis in the world, is associated with suffering due to pain, productivity loss, decreased mobility and quality of life. Systemic therapies available for OA are mostly symptom modifying and have potential gastrointestinal, renal, hepatic, and cardiac side effects. BMC Musculoskeletal Disorders recently published a study showing evidence of reparative effects demonstrated by homing of intra-articularly injected autologous bone marrow stem cells in damaged cartilage in an animal model of OA, along with clinical and radiographic benefit. This finding adds to the growing literature showing the potential benefit of intra-articular (IA) bone marrow stem cells. Other emerging potential IA therapies include IL-1 receptor antagonists, conditioned autologous serum, botulinum toxin, and bone morphogenetic protein-7. For each of these therapies, trial data in humans have been published, but more studies are needed to establish that they are safe and effective. Several additional promising new OA treatments are on the horizon, but challenges remain to finding safe and effective local and systemic therapies for OA. Please see related article: http://www.biomedcentral.com/1471-2474/12/259
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spelling pubmed-33649072012-06-01 Stem cells and other innovative intra-articular therapies for osteoarthritis: what does the future hold? Singh, Jasvinder A BMC Med Commentary Osteoarthritis (OA), the most common type of arthritis in the world, is associated with suffering due to pain, productivity loss, decreased mobility and quality of life. Systemic therapies available for OA are mostly symptom modifying and have potential gastrointestinal, renal, hepatic, and cardiac side effects. BMC Musculoskeletal Disorders recently published a study showing evidence of reparative effects demonstrated by homing of intra-articularly injected autologous bone marrow stem cells in damaged cartilage in an animal model of OA, along with clinical and radiographic benefit. This finding adds to the growing literature showing the potential benefit of intra-articular (IA) bone marrow stem cells. Other emerging potential IA therapies include IL-1 receptor antagonists, conditioned autologous serum, botulinum toxin, and bone morphogenetic protein-7. For each of these therapies, trial data in humans have been published, but more studies are needed to establish that they are safe and effective. Several additional promising new OA treatments are on the horizon, but challenges remain to finding safe and effective local and systemic therapies for OA. Please see related article: http://www.biomedcentral.com/1471-2474/12/259 BioMed Central 2012-05-02 /pmc/articles/PMC3364907/ /pubmed/22551396 http://dx.doi.org/10.1186/1741-7015-10-44 Text en Copyright ©2012 Singh; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Commentary
Singh, Jasvinder A
Stem cells and other innovative intra-articular therapies for osteoarthritis: what does the future hold?
title Stem cells and other innovative intra-articular therapies for osteoarthritis: what does the future hold?
title_full Stem cells and other innovative intra-articular therapies for osteoarthritis: what does the future hold?
title_fullStr Stem cells and other innovative intra-articular therapies for osteoarthritis: what does the future hold?
title_full_unstemmed Stem cells and other innovative intra-articular therapies for osteoarthritis: what does the future hold?
title_short Stem cells and other innovative intra-articular therapies for osteoarthritis: what does the future hold?
title_sort stem cells and other innovative intra-articular therapies for osteoarthritis: what does the future hold?
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3364907/
https://www.ncbi.nlm.nih.gov/pubmed/22551396
http://dx.doi.org/10.1186/1741-7015-10-44
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