The App-Runx1 Region Is Critical for Birth Defects and Electrocardiographic Dysfunctions Observed in a Down Syndrome Mouse Model

Down syndrome (DS) leads to complex phenotypes and is the main genetic cause of birth defects and heart diseases. The Ts65Dn DS mouse model is trisomic for the distal part of mouse chromosome 16 and displays similar features with post-natal lethality and cardiovascular defects. In order to better un...

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Detalles Bibliográficos
Autores principales: Raveau, Matthieu, Lignon, Jacques M., Nalesso, Valérie, Duchon, Arnaud, Groner, Yoram, Sharp, Andrew J., Dembele, Doulaye, Brault, Véronique, Hérault, Yann
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3364940/
https://www.ncbi.nlm.nih.gov/pubmed/22693452
http://dx.doi.org/10.1371/journal.pgen.1002724

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3364940/
https://www.ncbi.nlm.nih.gov/pubmed/22693452
http://dx.doi.org/10.1371/journal.pgen.1002724

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