Cargando…

The App-Runx1 Region Is Critical for Birth Defects and Electrocardiographic Dysfunctions Observed in a Down Syndrome Mouse Model

Down syndrome (DS) leads to complex phenotypes and is the main genetic cause of birth defects and heart diseases. The Ts65Dn DS mouse model is trisomic for the distal part of mouse chromosome 16 and displays similar features with post-natal lethality and cardiovascular defects. In order to better un...

Descripción completa

Detalles Bibliográficos
Autores principales:	Raveau, Matthieu, Lignon, Jacques M., Nalesso, Valérie, Duchon, Arnaud, Groner, Yoram, Sharp, Andrew J., Dembele, Doulaye, Brault, Véronique, Hérault, Yann
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3364940/ https://www.ncbi.nlm.nih.gov/pubmed/22693452 http://dx.doi.org/10.1371/journal.pgen.1002724

Ejemplares similares

Deletion of the App-Runx1 region in mice models human partial monosomy 21
por: Arbogast, Thomas, et al.
Publicado: (2015)

Identification of the translocation breakpoints in the Ts65Dn and Ts1Cje mouse lines: relevance for modeling down syndrome
por: Duchon, Arnaud, et al.
Publicado: (2011)

Controlled Somatic and Germline Copy Number Variation in the Mouse Model
por: Hérault, Yann, et al.
Publicado: (2010)

Dyrk1a from Gene Function in Development and Physiology to Dosage Correction across Life Span in Down Syndrome
por: Atas-Ozcan, Helin, et al.
Publicado: (2021)

Opposite Phenotypes of Muscle Strength and Locomotor Function in Mouse Models of Partial Trisomy and Monosomy 21 for the Proximal Hspa13-App Region
por: Brault, Véronique, et al.
Publicado: (2015)

Modeling Chromosomes in Mouse to Explore the Function of Genes, Genomic Disorders, and Chromosomal Organization
por: Brault, Véronique, et al.
Publicado: (2006)

The telomeric part of the human chromosome 21 from Cstb to Prmt2 is not necessary for the locomotor and short-term memory deficits observed in the Tc1 mouse model of Down syndrome
por: Duchon, Arnaud, et al.
Publicado: (2011)

DYRK1A, a Dosage-Sensitive Gene Involved in Neurodevelopmental Disorders, Is a Target for Drug Development in Down Syndrome
por: Duchon, Arnaud, et al.
Publicado: (2016)

Multi-influential genetic interactions alter behaviour and cognition through six main biological cascades in Down syndrome mouse models
por: Duchon, Arnaud, et al.
Publicado: (2021)

Dosage of the Abcg1-U2af1 Region Modifies Locomotor and Cognitive Deficits Observed in the Tc1 Mouse Model of Down Syndrome
por: Marechal, Damien, et al.
Publicado: (2015)

Prenatal treatment with EGCG enriched green tea extract rescues GAD67 related developmental and cognitive defects in Down syndrome mouse models
por: Souchet, Benoit, et al.
Publicado: (2019)

Characterization of PTZ-Induced Seizure Susceptibility in a Down Syndrome Mouse Model That Overexpresses CSTB
por: Brault, Véronique, et al.
Publicado: (2011)

Ts66Yah, a mouse model of Down syndrome with improved construct and face validity
por: Duchon, Arnaud, et al.
Publicado: (2022)

Author reply to: RUNX3 is expressed in the epithelium of the gastrointestinal tract
por: Levanon, Ditsa, et al.
Publicado: (2012)

Rodent models in Down syndrome research: impact and future opportunities
por: Herault, Yann, et al.
Publicado: (2017)

Runx3-mediated Transcriptional Program in Cytotoxic Lymphocytes
por: Lotem, Joseph, et al.
Publicado: (2013)

A new mouse model for the trisomy of the Abcg1–U2af1 region reveals the complexity of the combinatorial genetic code of down syndrome
por: Pereira, Patricia Lopes, et al.
Publicado: (2009)

Genomic-wide transcriptional profiling in primary myoblasts reveals Runx1-regulated genes in muscle regeneration
por: Umansky, Kfir Baruch, et al.
Publicado: (2015)

The effects of Cstb duplication on APP/amyloid-β pathology and cathepsin B activity in a mouse model
por: Wu, Yixing, et al.
Publicado: (2021)

A Flexible Microarray Data Simulation Model
por: Dembélé, Doulaye
Publicado: (2013)

Pharmacological correction of excitation/inhibition imbalance in Down syndrome mouse models
por: Souchet, Benoit, et al.
Publicado: (2015)

Long‐lasting correction of in vivo LTP and cognitive deficits of mice modelling Down syndrome with an α5‐selective GABA(A) inverse agonist
por: Duchon, Arnaud, et al.
Publicado: (2020)

Cell-Autonomous Function of Runx1 Transcriptionally Regulates Mouse Megakaryocytic Maturation
por: Pencovich, Niv, et al.
Publicado: (2013)

DYRK1A, a Novel Determinant of the Methionine-Homocysteine Cycle in Different Mouse Models Overexpressing this Down-Syndrome-Associated Kinase
por: Noll, Christophe, et al.
Publicado: (2009)

Runx1 Transcription Factor Is Required for Myoblasts Proliferation during Muscle Regeneration
por: Umansky, Kfir Baruch, et al.
Publicado: (2015)

Fold change rank ordering statistics: a new method for detecting differentially expressed genes
por: Dembélé, Doulaye, et al.
Publicado: (2014)

Comments on: fold change rank ordering statistics: a new method for detecting differentially expressed genes
por: Dembélé, Doulaye, et al.
Publicado: (2016)

Cognition and Hippocampal Plasticity in the Mouse Is Altered by Monosomy of a Genomic Region Implicated in Down Syndrome
por: Sahún, Ignasi, et al.
Publicado: (2014)

Developmentally regulated promoter-switch transcriptionally controls Runx1 function during embryonic hematopoiesis
por: Pozner, Amir, et al.
Publicado: (2007)

Runx3 prevents spontaneous colitis by directing the differentiation of anti-inflammatory mononuclear phagocytes
por: Hantisteanu, Shay, et al.
Publicado: (2020)

Runx3 and T-box proteins cooperate to establish the transcriptional program of effector CTLs
por: Cruz-Guilloty, Fernando, et al.
Publicado: (2009)

Transcriptional Reprogramming of CD11b(+)Esam(hi) Dendritic Cell Identity and Function by Loss of Runx3
por: Dicken, Joseph, et al.
Publicado: (2013)

The evolutionary origin of the Runx/CBFbeta transcription factors – Studies of the most basal metazoans
por: Sullivan, James C, et al.
Publicado: (2008)

Runx3 specifies lineage commitment of innate lymphoid cells
por: Ebihara, Takashi, et al.
Publicado: (2015)

Absence of Runx3 expression in normal gastrointestinal epithelium calls into question its tumour suppressor function
por: Levanon, Ditsa, et al.
Publicado: (2011)

Noninvasive Mapping of Repolarization With Electrocardiographic Imaging
por: Rudy, Yoram
Publicado: (2021)

Correction of cognitive deficits in mouse models of Down syndrome by a pharmacological inhibitor of DYRK1A
por: Nguyen, Thu Lan, et al.
Publicado: (2018)

Targeting the RHOA pathway improves learning and memory in adult Kctd13 and 16p11.2 deletion mouse models
por: Martin Lorenzo, Sandra, et al.
Publicado: (2021)

Mof-associated complexes have overlapping and unique roles in regulating pluripotency in embryonic stem cells and during differentiation
por: Ravens, Sarina, et al.
Publicado: (2014)

RUNX represses Pmp22 to drive neurofibromagenesis
por: Hall, Ashley, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_hq6bku3gioilpqlodhhaskkro6