Cargando…

Transcriptional Profiling of Human Brain Endothelial Cells Reveals Key Properties Crucial for Predictive In Vitro Blood-Brain Barrier Models

Brain microvascular endothelial cells (BEC) constitute the blood-brain barrier (BBB) which forms a dynamic interface between the blood and the central nervous system (CNS). This highly specialized interface restricts paracellular diffusion of fluids and solutes including chemicals, toxins and drugs...

Descripción completa

Detalles Bibliográficos
Autores principales:	Urich, Eduard, Lazic, Stanley E., Molnos, Juliette, Wells, Isabelle, Freskgård, Per-Ola
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3364980/ https://www.ncbi.nlm.nih.gov/pubmed/22675443 http://dx.doi.org/10.1371/journal.pone.0038149

Ejemplares similares

Multicellular Self-Assembled Spheroidal Model of the Blood Brain Barrier
por: Urich, Eduard, et al.
Publicado: (2013)

Brain Shuttle Neprilysin reduces central Amyloid-β levels
por: Campos, Christopher R., et al.
Publicado: (2020)

Trafficking of Endogenous Immunoglobulins by Endothelial Cells at the Blood-Brain Barrier
por: Villaseñor, Roberto, et al.
Publicado: (2016)

Cargo Delivery into the Brain by in vivo identified Transport Peptides
por: Urich, Eduard, et al.
Publicado: (2015)

A Human Blood-Brain Barrier Transcytosis Assay Reveals Antibody Transcytosis Influenced by pH-Dependent Receptor Binding
por: Sade, Hadassah, et al.
Publicado: (2014)

Gliovascular and cytokine interactions modulate brain endothelial barrier in vitro
por: Chaitanya, Ganta V, et al.
Publicado: (2011)

Stretch in Brain Microvascular Endothelial Cells (cEND) as an In Vitro Traumatic Brain Injury Model of the Blood Brain Barrier
por: Salvador, Ellaine, et al.
Publicado: (2013)

Generation of an Immortalized Murine Brain Microvascular Endothelial Cell Line as an In Vitro Blood Brain Barrier Model
por: Burek, Malgorzata, et al.
Publicado: (2012)

Brain endothelial LRP1 maintains blood–brain barrier integrity
por: Storck, Steffen E., et al.
Publicado: (2021)

Optimization of endothelial cell growth in a murine in vitro blood–brain barrier model
por: Wuest, Diane M, et al.
Publicado: (2012)

Morphological and Functional Effects of Ultrasound on Blood–Brain Barrier Transitory Opening: An In Vitro Study on Rat Brain Endothelial Cells
por: Branca, Jacopo Junio Valerio, et al.
Publicado: (2023)

Brain endothelial tricellular junctions as novel sites for T cell diapedesis across the blood–brain barrier
por: Castro Dias, Mariana, et al.
Publicado: (2021)

Brain Endothelial Cell-Cell Junctions: How to “Open” the Blood Brain Barrier
por: Stamatovic, Svetlana M, et al.
Publicado: (2008)

Cytoskeleton Elements Contribute to Prion Peptide-Induced Endothelial Barrier Breakdown in a Blood–Brain Barrier In Vitro System
por: Cooper, Itzik, et al.
Publicado: (2022)

Wnt Activation of Immortalized Brain Endothelial Cells as a Tool for Generating a Standardized Model of the Blood Brain Barrier In Vitro
por: Paolinelli, Roberta, et al.
Publicado: (2013)

Instruction of Circulating Endothelial Progenitors In Vitro towards Specialized Blood-Brain Barrier and Arterial Phenotypes
por: Ponio, Julie Boyer-Di, et al.
Publicado: (2014)

The effect of nanoparticle size on the probability to cross the blood-brain barrier: an in-vitro endothelial cell model
por: Shilo, Malka, et al.
Publicado: (2015)

In Vitro Induction of Endothelial Apoptosis of the Post-Hypoxic Blood-Brain Barrier by Isoflurane but Not by Sevoflurane and Midazolam
por: Dittmar, Michael S., et al.
Publicado: (2015)

Direct Current Stimulation Disrupts Endothelial Glycocalyx and Tight Junctions of the Blood-Brain Barrier in vitro
por: Xia, Yifan, et al.
Publicado: (2021)

Cladribine Reduces Trans-Endothelial Migration of Memory T Cells across an In Vitro Blood–Brain Barrier
por: Ford, Rachel K., et al.
Publicado: (2022)

In Vitro Blood-Brain Barrier Models Using Brain Capillary Endothelial Cells Isolated from Neonatal and Adult Rats Retain Age-Related Barrier Properties
por: Takata, Fuyuko, et al.
Publicado: (2013)

Endothelial tight junctions form the blood–brain barrier
por: Bonetta, Laura
Publicado: (2005)

Holey barrier: claudins and the regulation of brain endothelial permeability
por: Matter, Karl, et al.
Publicado: (2003)

Endothelial Dysfunction in the Context of Blood–Brain Barrier Modeling
por: Kutikhin, A. G., et al.
Publicado: (2022)

Bridging Waves and Crucial Events in the Dynamics of the Brain
por: Bohara, Gyanendra, et al.
Publicado: (2018)

Blood–brain barrier endothelial cells in neurodegenerative diseases: Signals from the “barrier”
por: Yuan, Yiwen, et al.
Publicado: (2023)

Brain microvascular endothelial-astrocyte cell responses following Japanese encephalitis virus infection in an in vitro human blood-brain barrier model
por: Patabendige, Adjanie, et al.
Publicado: (2018)

Impairment of brain endothelial glucose transporter by methamphetamine causes blood-brain barrier dysfunction
por: Abdul Muneer, P M, et al.
Publicado: (2011)

Effects of Rapamycin on Insulin Brain Endothelial Cell Binding and Blood–Brain Barrier Transport
por: Nguyen, Steven, et al.
Publicado: (2021)

Altered Nrf2 Signaling Mediates Hypoglycemia-Induced Blood–Brain Barrier Endothelial Dysfunction In Vitro
por: Sajja, Ravi K., et al.
Publicado: (2015)

SPARC expression by cerebral microvascular endothelial cells in vitro and its influence on blood-brain barrier properties
por: Alkabie, Samir, et al.
Publicado: (2016)

Increased Catecholamine Levels and Inflammatory Mediators Alter Barrier Properties of Brain Microvascular Endothelial Cells in vitro
por: Ittner, Cora, et al.
Publicado: (2020)

Human CD4(+) T cell subsets differ in their abilities to cross endothelial and epithelial brain barriers in vitro
por: Nishihara, Hideaki, et al.
Publicado: (2020)

In vitro model of brain endothelial cell barrier reveals alterations induced by Plasmodium blood stage factors
por: Pais, Teresa F., et al.
Publicado: (2023)

Engineering the human blood-brain barrier in vitro
por: Jamieson, John J., et al.
Publicado: (2017)

Potent and Selective BACE-1 Peptide Inhibitors Lower Brain Aβ Levels Mediated by Brain Shuttle Transport
por: Ruderisch, Nadine, et al.
Publicado: (2017)

The role of shear stress in Blood-Brain Barrier endothelial physiology
por: Cucullo, Luca, et al.
Publicado: (2011)

Interplay of Plasmodium falciparum and thrombin in brain endothelial barrier disruption
por: Avril, Marion, et al.
Publicado: (2019)

Structure and Junctional Complexes of Endothelial, Epithelial and Glial Brain Barriers
por: Castro Dias, Mariana, et al.
Publicado: (2019)

Hypothiocyanous Acid Disrupts the Barrier Function of Brain Endothelial Cells
por: van Leeuwen, Eveline, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_9pn39nujsjjigkghvu3ch6kj55