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Individual Variations in Maternal Care Early in Life Correlate with Later Life Decision-Making and c-Fos Expression in Prefrontal Subregions of Rats

Early life adversity affects hypothalamus-pituitary-adrenal axis activity, alters cognitive functioning and in humans is thought to increase the vulnerability to psychopathology–e.g. depression, anxiety and schizophrenia- later in life. Here we investigated whether subtle natural variations among in...

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Autores principales: van Hasselt, Felisa N., de Visser, Leonie, Tieskens, Jacintha M., Cornelisse, Sandra, Baars, Annemarie M., Lavrijsen, Marla, Krugers, Harm J., van den Bos, Ruud, Joëls, Marian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3365050/
https://www.ncbi.nlm.nih.gov/pubmed/22693577
http://dx.doi.org/10.1371/journal.pone.0037820
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author van Hasselt, Felisa N.
de Visser, Leonie
Tieskens, Jacintha M.
Cornelisse, Sandra
Baars, Annemarie M.
Lavrijsen, Marla
Krugers, Harm J.
van den Bos, Ruud
Joëls, Marian
author_facet van Hasselt, Felisa N.
de Visser, Leonie
Tieskens, Jacintha M.
Cornelisse, Sandra
Baars, Annemarie M.
Lavrijsen, Marla
Krugers, Harm J.
van den Bos, Ruud
Joëls, Marian
author_sort van Hasselt, Felisa N.
collection PubMed
description Early life adversity affects hypothalamus-pituitary-adrenal axis activity, alters cognitive functioning and in humans is thought to increase the vulnerability to psychopathology–e.g. depression, anxiety and schizophrenia- later in life. Here we investigated whether subtle natural variations among individual rat pups in the amount of maternal care received, i.e. differences in the amount of licking and grooming (LG), correlate with anxiety and prefrontal cortex-dependent behavior in young adulthood. Therefore, we examined the correlation between LG received during the first postnatal week and later behavior in the elevated plus maze and in decision-making processes using a rodent version of the Iowa Gambling Task (rIGT). In our cohort of male and female animals a high degree of LG correlated with less anxiety in the elevated plus maze and more advantageous choices during the last 10 trials of the rIGT. In tissue collected 2 hrs after completion of the task, the correlation between LG and c-fos expression (a marker of neuronal activity) was established in structures important for IGT performance. Negative correlations existed between rIGT performance and c-fos expression in the lateral orbitofrontal cortex, prelimbic cortex, infralimbic cortex and insular cortex. The insular cortex correlations between c-fos expression and decision-making performance depended on LG background; this was also true for the lateral orbitofrontal cortex in female rats. Dendritic complexity of insular or infralimbic pyramidal neurons did not or weakly correlate with LG background. We conclude that natural variations in maternal care received by pups may significantly contribute to later-life decision-making and activity of underlying brain structures.
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spelling pubmed-33650502012-06-12 Individual Variations in Maternal Care Early in Life Correlate with Later Life Decision-Making and c-Fos Expression in Prefrontal Subregions of Rats van Hasselt, Felisa N. de Visser, Leonie Tieskens, Jacintha M. Cornelisse, Sandra Baars, Annemarie M. Lavrijsen, Marla Krugers, Harm J. van den Bos, Ruud Joëls, Marian PLoS One Research Article Early life adversity affects hypothalamus-pituitary-adrenal axis activity, alters cognitive functioning and in humans is thought to increase the vulnerability to psychopathology–e.g. depression, anxiety and schizophrenia- later in life. Here we investigated whether subtle natural variations among individual rat pups in the amount of maternal care received, i.e. differences in the amount of licking and grooming (LG), correlate with anxiety and prefrontal cortex-dependent behavior in young adulthood. Therefore, we examined the correlation between LG received during the first postnatal week and later behavior in the elevated plus maze and in decision-making processes using a rodent version of the Iowa Gambling Task (rIGT). In our cohort of male and female animals a high degree of LG correlated with less anxiety in the elevated plus maze and more advantageous choices during the last 10 trials of the rIGT. In tissue collected 2 hrs after completion of the task, the correlation between LG and c-fos expression (a marker of neuronal activity) was established in structures important for IGT performance. Negative correlations existed between rIGT performance and c-fos expression in the lateral orbitofrontal cortex, prelimbic cortex, infralimbic cortex and insular cortex. The insular cortex correlations between c-fos expression and decision-making performance depended on LG background; this was also true for the lateral orbitofrontal cortex in female rats. Dendritic complexity of insular or infralimbic pyramidal neurons did not or weakly correlate with LG background. We conclude that natural variations in maternal care received by pups may significantly contribute to later-life decision-making and activity of underlying brain structures. Public Library of Science 2012-05-31 /pmc/articles/PMC3365050/ /pubmed/22693577 http://dx.doi.org/10.1371/journal.pone.0037820 Text en van Hasselt et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
van Hasselt, Felisa N.
de Visser, Leonie
Tieskens, Jacintha M.
Cornelisse, Sandra
Baars, Annemarie M.
Lavrijsen, Marla
Krugers, Harm J.
van den Bos, Ruud
Joëls, Marian
Individual Variations in Maternal Care Early in Life Correlate with Later Life Decision-Making and c-Fos Expression in Prefrontal Subregions of Rats
title Individual Variations in Maternal Care Early in Life Correlate with Later Life Decision-Making and c-Fos Expression in Prefrontal Subregions of Rats
title_full Individual Variations in Maternal Care Early in Life Correlate with Later Life Decision-Making and c-Fos Expression in Prefrontal Subregions of Rats
title_fullStr Individual Variations in Maternal Care Early in Life Correlate with Later Life Decision-Making and c-Fos Expression in Prefrontal Subregions of Rats
title_full_unstemmed Individual Variations in Maternal Care Early in Life Correlate with Later Life Decision-Making and c-Fos Expression in Prefrontal Subregions of Rats
title_short Individual Variations in Maternal Care Early in Life Correlate with Later Life Decision-Making and c-Fos Expression in Prefrontal Subregions of Rats
title_sort individual variations in maternal care early in life correlate with later life decision-making and c-fos expression in prefrontal subregions of rats
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3365050/
https://www.ncbi.nlm.nih.gov/pubmed/22693577
http://dx.doi.org/10.1371/journal.pone.0037820
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