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Changes in dopamine D2-receptor binding are associated to symptom reduction after psychotherapy in social anxiety disorder
The dopamine system has been suggested to play a role in social anxiety disorder (SAD), partly based on molecular imaging studies showing reduced levels of striatal dopaminergic markers in patients compared with control subjects. However, the dopamine system has not been examined in frontal and limb...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3365259/ https://www.ncbi.nlm.nih.gov/pubmed/22832965 http://dx.doi.org/10.1038/tp.2012.40 |
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author | Cervenka, S Hedman, E Ikoma, Y Djurfeldt, D Radu Rück, C Halldin, C Lindefors, N |
author_facet | Cervenka, S Hedman, E Ikoma, Y Djurfeldt, D Radu Rück, C Halldin, C Lindefors, N |
author_sort | Cervenka, S |
collection | PubMed |
description | The dopamine system has been suggested to play a role in social anxiety disorder (SAD), partly based on molecular imaging studies showing reduced levels of striatal dopaminergic markers in patients compared with control subjects. However, the dopamine system has not been examined in frontal and limbic brain regions proposed to be central in the pathophysiology of SAD. In the present study, we hypothesized that extrastriatal dopamine D2-receptor (D2-R) levels measured using positron emission tomography (PET) would predict symptom reduction after cognitive behavior therapy (CBT). Nine SAD patients were examined using high-resolution PET and the high-affinity D2-R antagonist radioligand [(11)C]FLB 457, before and after 15 weeks of CBT. Symptom levels were assessed using the anxiety subscale of Liebowitz Social Anxiety Scale (LSAS(anx)). At posttreatment, there was a statistically significant reduction of social anxiety symptoms (P<0.005). Using a repeated measures analysis of covariance, significant effects for time and time × LSAS(anx) change on D2-R-binding potential (BP(ND)) were shown (P<0.05). In a subsequent region-by-region analysis, negative correlations between change in D2-R BP(ND) and LSAS(anx) change were found for medial prefrontal cortex and hippocampus (P<0.05). This is the first study to report a direct relationship between symptom change after psychological treatment and a marker of brain neurotransmission. Using an intra-individual comparison design, the study supports a role for the dopamine system in cortical and limbic brain regions in the pathophysiology of SAD. |
format | Online Article Text |
id | pubmed-3365259 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-33652592012-06-01 Changes in dopamine D2-receptor binding are associated to symptom reduction after psychotherapy in social anxiety disorder Cervenka, S Hedman, E Ikoma, Y Djurfeldt, D Radu Rück, C Halldin, C Lindefors, N Transl Psychiatry Original Article The dopamine system has been suggested to play a role in social anxiety disorder (SAD), partly based on molecular imaging studies showing reduced levels of striatal dopaminergic markers in patients compared with control subjects. However, the dopamine system has not been examined in frontal and limbic brain regions proposed to be central in the pathophysiology of SAD. In the present study, we hypothesized that extrastriatal dopamine D2-receptor (D2-R) levels measured using positron emission tomography (PET) would predict symptom reduction after cognitive behavior therapy (CBT). Nine SAD patients were examined using high-resolution PET and the high-affinity D2-R antagonist radioligand [(11)C]FLB 457, before and after 15 weeks of CBT. Symptom levels were assessed using the anxiety subscale of Liebowitz Social Anxiety Scale (LSAS(anx)). At posttreatment, there was a statistically significant reduction of social anxiety symptoms (P<0.005). Using a repeated measures analysis of covariance, significant effects for time and time × LSAS(anx) change on D2-R-binding potential (BP(ND)) were shown (P<0.05). In a subsequent region-by-region analysis, negative correlations between change in D2-R BP(ND) and LSAS(anx) change were found for medial prefrontal cortex and hippocampus (P<0.05). This is the first study to report a direct relationship between symptom change after psychological treatment and a marker of brain neurotransmission. Using an intra-individual comparison design, the study supports a role for the dopamine system in cortical and limbic brain regions in the pathophysiology of SAD. Nature Publishing Group 2012-05 2012-05-22 /pmc/articles/PMC3365259/ /pubmed/22832965 http://dx.doi.org/10.1038/tp.2012.40 Text en Copyright © 2012 Macmillan Publishers Limited http://creativecommons.org/licenses/by-nc-nd/3.0/ This work is licensed under the Creative Commons Attribution-NonCommercial-No Derivative Works 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/ |
spellingShingle | Original Article Cervenka, S Hedman, E Ikoma, Y Djurfeldt, D Radu Rück, C Halldin, C Lindefors, N Changes in dopamine D2-receptor binding are associated to symptom reduction after psychotherapy in social anxiety disorder |
title | Changes in dopamine D2-receptor binding are associated to symptom reduction after psychotherapy in social anxiety disorder |
title_full | Changes in dopamine D2-receptor binding are associated to symptom reduction after psychotherapy in social anxiety disorder |
title_fullStr | Changes in dopamine D2-receptor binding are associated to symptom reduction after psychotherapy in social anxiety disorder |
title_full_unstemmed | Changes in dopamine D2-receptor binding are associated to symptom reduction after psychotherapy in social anxiety disorder |
title_short | Changes in dopamine D2-receptor binding are associated to symptom reduction after psychotherapy in social anxiety disorder |
title_sort | changes in dopamine d2-receptor binding are associated to symptom reduction after psychotherapy in social anxiety disorder |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3365259/ https://www.ncbi.nlm.nih.gov/pubmed/22832965 http://dx.doi.org/10.1038/tp.2012.40 |
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