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Circadian profiles in young people during the early stages of affective disorder

Although disturbances of the circadian system are strongly linked to affective disorders, no known studies have examined melatonin profiles in young people in early stages of illness. In this study, 44 patients with an affective disorder underwent clinical and neuropsychological assessments. They we...

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Autores principales: Naismith, S L, Hermens, D F, Ip, T K C, Bolitho, S, Scott, E, Rogers, N L, Hickie, I B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3365266/
https://www.ncbi.nlm.nih.gov/pubmed/22832967
http://dx.doi.org/10.1038/tp.2012.47
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author Naismith, S L
Hermens, D F
Ip, T K C
Bolitho, S
Scott, E
Rogers, N L
Hickie, I B
author_facet Naismith, S L
Hermens, D F
Ip, T K C
Bolitho, S
Scott, E
Rogers, N L
Hickie, I B
author_sort Naismith, S L
collection PubMed
description Although disturbances of the circadian system are strongly linked to affective disorders, no known studies have examined melatonin profiles in young people in early stages of illness. In this study, 44 patients with an affective disorder underwent clinical and neuropsychological assessments. They were then rated by a psychiatrist according to a clinical staging model and were categorized as having an ‘attenuated syndrome' or an ‘established disorder'. During the evening, salivary melatonin was sampled under dim light conditions over an 8-h interval and for each patient, the time of melatonin onset, total area under the curve and phase angle (difference between time of melatonin onset and time of habitual sleep onset) were computed. Results showed that there was no difference in the timing of melatonin onset across illness stages. However, area under the curve analyses showed that those patients with ‘established disorders' had markedly reduced levels of melatonin secretion, and shorter phase angles, relative to those with ‘attenuated syndromes'. These lower levels, in turn, were related to lower subjective sleepiness, and poorer performance on neuropsychological tests of verbal memory. Overall, these results suggest that for patients with established illness, dysfunction of the circadian system relates clearly to functional features and markers of underlying neurobiological change. Although the interpretation of these results would be greatly enhanced by control data, this work has important implications for the early delivery of chronobiological interventions in young people with affective disorders.
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spelling pubmed-33652662012-06-01 Circadian profiles in young people during the early stages of affective disorder Naismith, S L Hermens, D F Ip, T K C Bolitho, S Scott, E Rogers, N L Hickie, I B Transl Psychiatry Original Article Although disturbances of the circadian system are strongly linked to affective disorders, no known studies have examined melatonin profiles in young people in early stages of illness. In this study, 44 patients with an affective disorder underwent clinical and neuropsychological assessments. They were then rated by a psychiatrist according to a clinical staging model and were categorized as having an ‘attenuated syndrome' or an ‘established disorder'. During the evening, salivary melatonin was sampled under dim light conditions over an 8-h interval and for each patient, the time of melatonin onset, total area under the curve and phase angle (difference between time of melatonin onset and time of habitual sleep onset) were computed. Results showed that there was no difference in the timing of melatonin onset across illness stages. However, area under the curve analyses showed that those patients with ‘established disorders' had markedly reduced levels of melatonin secretion, and shorter phase angles, relative to those with ‘attenuated syndromes'. These lower levels, in turn, were related to lower subjective sleepiness, and poorer performance on neuropsychological tests of verbal memory. Overall, these results suggest that for patients with established illness, dysfunction of the circadian system relates clearly to functional features and markers of underlying neurobiological change. Although the interpretation of these results would be greatly enhanced by control data, this work has important implications for the early delivery of chronobiological interventions in young people with affective disorders. Nature Publishing Group 2012-05 2012-05-29 /pmc/articles/PMC3365266/ /pubmed/22832967 http://dx.doi.org/10.1038/tp.2012.47 Text en Copyright © 2012 Macmillan Publishers Limited http://creativecommons.org/licenses/by-nc-nd/3.0/ This work is licensed under the Creative Commons Attribution-NonCommercial-No Derivative Works 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/
spellingShingle Original Article
Naismith, S L
Hermens, D F
Ip, T K C
Bolitho, S
Scott, E
Rogers, N L
Hickie, I B
Circadian profiles in young people during the early stages of affective disorder
title Circadian profiles in young people during the early stages of affective disorder
title_full Circadian profiles in young people during the early stages of affective disorder
title_fullStr Circadian profiles in young people during the early stages of affective disorder
title_full_unstemmed Circadian profiles in young people during the early stages of affective disorder
title_short Circadian profiles in young people during the early stages of affective disorder
title_sort circadian profiles in young people during the early stages of affective disorder
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3365266/
https://www.ncbi.nlm.nih.gov/pubmed/22832967
http://dx.doi.org/10.1038/tp.2012.47
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