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Absence of Ca(2+)-stimulated adenylyl cyclases leads to reduced synaptic plasticity and impaired experience-dependent fear memory
Ca(2+)-stimulated adenylyl cyclase (AC) 1 and 8 are two genes that have been shown to play critical roles in fear memory. AC1 and AC8 couple neuronal activity and intracellular Ca(2+) increases to the production of cyclic adenosine monophosphate and are localized synaptically, suggesting that Ca(2+)...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3365269/ https://www.ncbi.nlm.nih.gov/pubmed/22832970 http://dx.doi.org/10.1038/tp.2012.50 |