Absence of Ca(2+)-stimulated adenylyl cyclases leads to reduced synaptic plasticity and impaired experience-dependent fear memory

Ca(2+)-stimulated adenylyl cyclase (AC) 1 and 8 are two genes that have been shown to play critical roles in fear memory. AC1 and AC8 couple neuronal activity and intracellular Ca(2+) increases to the production of cyclic adenosine monophosphate and are localized synaptically, suggesting that Ca(2+)...

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Detalles Bibliográficos
Autores principales: Wieczorek, L, Majumdar, D, Wills, T A, Hu, L, Winder, D G, Webb, D J, Muglia, L J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2012
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3365269/
https://www.ncbi.nlm.nih.gov/pubmed/22832970
http://dx.doi.org/10.1038/tp.2012.50

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