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The transposon-driven evolutionary origin and basis of histone deacetylase functions and limitations in disease prevention
Histone deacetylases (HDACs) are homologous to prokaryotic enzymes that removed acetyl groups from non-histone proteins before the evolution of eukaryotic histones. Enzymes inherited from prokaryotes or from a common ancestor were adapted for histone deacetylation, while useful deacetylation of non-...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Springer-Verlag
2011
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3365375/ https://www.ncbi.nlm.nih.gov/pubmed/22704332 http://dx.doi.org/10.1007/s13148-011-0020-z |