Epigenetic regulation of mucin genes in human cancers

Mucins are high molecular weight glycoproteins that play important roles in diagnostic and prognostic prediction and in carcinogenesis and tumor invasion. Regulation of expression of mucin genes has been studied extensively, and signaling pathways, transcriptional regulators, and epigenetic modifica...

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Autores principales: Yamada, Norishige, Kitamoto, Sho, Yokoyama, Seiya, Hamada, Tomofumi, Goto, Masamichi, Tsutsumida, Hideaki, Higashi, Michiyo, Yonezawa, Suguru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer-Verlag 2011
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3365379/
https://www.ncbi.nlm.nih.gov/pubmed/22704331
http://dx.doi.org/10.1007/s13148-011-0037-3
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author Yamada, Norishige
Kitamoto, Sho
Yokoyama, Seiya
Hamada, Tomofumi
Goto, Masamichi
Tsutsumida, Hideaki
Higashi, Michiyo
Yonezawa, Suguru
author_facet Yamada, Norishige
Kitamoto, Sho
Yokoyama, Seiya
Hamada, Tomofumi
Goto, Masamichi
Tsutsumida, Hideaki
Higashi, Michiyo
Yonezawa, Suguru
author_sort Yamada, Norishige
collection PubMed
description Mucins are high molecular weight glycoproteins that play important roles in diagnostic and prognostic prediction and in carcinogenesis and tumor invasion. Regulation of expression of mucin genes has been studied extensively, and signaling pathways, transcriptional regulators, and epigenetic modification in promoter regions have been described. Detection of the epigenetic status of cancer-related mucin genes is important for early diagnosis of cancer and for monitoring of tumor behavior and response to targeted therapy. Effects of micro-RNAs on mucin gene expression have also started to emerge. In this review, we discuss the current views on epigenetic mechanisms of regulation of mucin genes (MUC1, MUC2, MUC3A, MUC4, MUC5AC, MUC5B, MUC6, MUC16, and MUC17) and the possible clinical applications of this epigenetic information.
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spelling pubmed-33653792012-06-02 Epigenetic regulation of mucin genes in human cancers Yamada, Norishige Kitamoto, Sho Yokoyama, Seiya Hamada, Tomofumi Goto, Masamichi Tsutsumida, Hideaki Higashi, Michiyo Yonezawa, Suguru Clin Epigenetics Review Mucins are high molecular weight glycoproteins that play important roles in diagnostic and prognostic prediction and in carcinogenesis and tumor invasion. Regulation of expression of mucin genes has been studied extensively, and signaling pathways, transcriptional regulators, and epigenetic modification in promoter regions have been described. Detection of the epigenetic status of cancer-related mucin genes is important for early diagnosis of cancer and for monitoring of tumor behavior and response to targeted therapy. Effects of micro-RNAs on mucin gene expression have also started to emerge. In this review, we discuss the current views on epigenetic mechanisms of regulation of mucin genes (MUC1, MUC2, MUC3A, MUC4, MUC5AC, MUC5B, MUC6, MUC16, and MUC17) and the possible clinical applications of this epigenetic information. Springer-Verlag 2011-05-01 /pmc/articles/PMC3365379/ /pubmed/22704331 http://dx.doi.org/10.1007/s13148-011-0037-3 Text en © Springer-Verlag 2011
spellingShingle Review
Yamada, Norishige
Kitamoto, Sho
Yokoyama, Seiya
Hamada, Tomofumi
Goto, Masamichi
Tsutsumida, Hideaki
Higashi, Michiyo
Yonezawa, Suguru
Epigenetic regulation of mucin genes in human cancers
title Epigenetic regulation of mucin genes in human cancers
title_full Epigenetic regulation of mucin genes in human cancers
title_fullStr Epigenetic regulation of mucin genes in human cancers
title_full_unstemmed Epigenetic regulation of mucin genes in human cancers
title_short Epigenetic regulation of mucin genes in human cancers
title_sort epigenetic regulation of mucin genes in human cancers
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3365379/
https://www.ncbi.nlm.nih.gov/pubmed/22704331
http://dx.doi.org/10.1007/s13148-011-0037-3
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