Microtermolides A and B from Termite-Associated Streptomyces sp. and Structural Revision of Vinylamycin

[Image: see text] Microtermolides A (1) and B (2) were isolated from a Streptomyces sp. strain associated with fungus-growing termites. The structures of 1 and 2 were determined by 1D- and 2D-NMR spectroscopy and high-resolution mass spectrometry. Structural elucidation of 1 led to the re-examinatio...

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Detalles Bibliográficos
Autores principales: Carr, Gavin, Poulsen, Michael, Klassen, Jonathan L., Hou, Yanpeng, Wyche, Thomas P., Bugni, Tim S., Currie, Cameron R., Clardy, Jon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2012
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3365539/
https://www.ncbi.nlm.nih.gov/pubmed/22591554
http://dx.doi.org/10.1021/ol301043p
Descripción
Sumario:[Image: see text] Microtermolides A (1) and B (2) were isolated from a Streptomyces sp. strain associated with fungus-growing termites. The structures of 1 and 2 were determined by 1D- and 2D-NMR spectroscopy and high-resolution mass spectrometry. Structural elucidation of 1 led to the re-examination of the structure originally proposed for vinylamycin (3). Based on a comparison of predicted and experimental (1)H and (13)C NMR chemical shifts, we propose that vinylamycin’s structure be revised from 3 to 4.

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