Microtermolides A and B from Termite-Associated Streptomyces sp. and Structural Revision of Vinylamycin

[Image: see text] Microtermolides A (1) and B (2) were isolated from a Streptomyces sp. strain associated with fungus-growing termites. The structures of 1 and 2 were determined by 1D- and 2D-NMR spectroscopy and high-resolution mass spectrometry. Structural elucidation of 1 led to the re-examinatio...

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Autores principales: Carr, Gavin, Poulsen, Michael, Klassen, Jonathan L., Hou, Yanpeng, Wyche, Thomas P., Bugni, Tim S., Currie, Cameron R., Clardy, Jon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2012
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3365539/
https://www.ncbi.nlm.nih.gov/pubmed/22591554
http://dx.doi.org/10.1021/ol301043p
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author Carr, Gavin
Poulsen, Michael
Klassen, Jonathan L.
Hou, Yanpeng
Wyche, Thomas P.
Bugni, Tim S.
Currie, Cameron R.
Clardy, Jon
author_facet Carr, Gavin
Poulsen, Michael
Klassen, Jonathan L.
Hou, Yanpeng
Wyche, Thomas P.
Bugni, Tim S.
Currie, Cameron R.
Clardy, Jon
author_sort Carr, Gavin
collection PubMed
description [Image: see text] Microtermolides A (1) and B (2) were isolated from a Streptomyces sp. strain associated with fungus-growing termites. The structures of 1 and 2 were determined by 1D- and 2D-NMR spectroscopy and high-resolution mass spectrometry. Structural elucidation of 1 led to the re-examination of the structure originally proposed for vinylamycin (3). Based on a comparison of predicted and experimental (1)H and (13)C NMR chemical shifts, we propose that vinylamycin’s structure be revised from 3 to 4.
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spelling pubmed-33655392012-06-01 Microtermolides A and B from Termite-Associated Streptomyces sp. and Structural Revision of Vinylamycin Carr, Gavin Poulsen, Michael Klassen, Jonathan L. Hou, Yanpeng Wyche, Thomas P. Bugni, Tim S. Currie, Cameron R. Clardy, Jon Org Lett [Image: see text] Microtermolides A (1) and B (2) were isolated from a Streptomyces sp. strain associated with fungus-growing termites. The structures of 1 and 2 were determined by 1D- and 2D-NMR spectroscopy and high-resolution mass spectrometry. Structural elucidation of 1 led to the re-examination of the structure originally proposed for vinylamycin (3). Based on a comparison of predicted and experimental (1)H and (13)C NMR chemical shifts, we propose that vinylamycin’s structure be revised from 3 to 4. American Chemical Society 2012-05-16 2012-06-01 /pmc/articles/PMC3365539/ /pubmed/22591554 http://dx.doi.org/10.1021/ol301043p Text en Copyright © 2012 American Chemical Society http://pubs.acs.org This is an open-access article distributed under the ACS AuthorChoice Terms & Conditions. Any use of this article, must conform to the terms of that license which are available at http://pubs.acs.org.
spellingShingle Carr, Gavin
Poulsen, Michael
Klassen, Jonathan L.
Hou, Yanpeng
Wyche, Thomas P.
Bugni, Tim S.
Currie, Cameron R.
Clardy, Jon
Microtermolides A and B from Termite-Associated Streptomyces sp. and Structural Revision of Vinylamycin
title Microtermolides A and B from Termite-Associated Streptomyces sp. and Structural Revision of Vinylamycin
title_full Microtermolides A and B from Termite-Associated Streptomyces sp. and Structural Revision of Vinylamycin
title_fullStr Microtermolides A and B from Termite-Associated Streptomyces sp. and Structural Revision of Vinylamycin
title_full_unstemmed Microtermolides A and B from Termite-Associated Streptomyces sp. and Structural Revision of Vinylamycin
title_short Microtermolides A and B from Termite-Associated Streptomyces sp. and Structural Revision of Vinylamycin
title_sort microtermolides a and b from termite-associated streptomyces sp. and structural revision of vinylamycin
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3365539/
https://www.ncbi.nlm.nih.gov/pubmed/22591554
http://dx.doi.org/10.1021/ol301043p
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