Characterization of Chromoshadow Domain-mediated Binding of Heterochromatin Protein 1α (HP1α) to Histone H3

The chromoshadow domain (CSD) of heterochromatin protein 1 (HP1) was recently shown to contribute to chromatin binding and transcriptional regulation through interaction with histone H3. Here, we demonstrate the structural basis of this interaction for the CSD of HP1α. This mode of H3 binding is dep...

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Detalles Bibliográficos
Autores principales: Richart, Alexandria N., Brunner, Clair I. W., Stott, Katherine, Murzina, Natalia V., Thomas, Jean O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2012
Materias:
Protein Structure and Folding
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3365711/
https://www.ncbi.nlm.nih.gov/pubmed/22493481
http://dx.doi.org/10.1074/jbc.M111.337204

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3365711/
https://www.ncbi.nlm.nih.gov/pubmed/22493481
http://dx.doi.org/10.1074/jbc.M111.337204

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