Detectable clonal mosaicism from birth to old age and its relationship to cancer

Clonal mosaicism for large chromosomal anomalies (duplications, deletions and uniparental disomy) was detected using SNP microarray data from over 50,000 subjects recruited for genome-wide association studies. This detection method requires a relatively high frequency of cells (>5–10%) with the s...

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Detalles Bibliográficos
Autores principales: Laurie, Cathy C., Laurie, Cecelia A., Rice, Kenneth, Doheny, Kimberly F., Zelnick, Leila R., McHugh, Caitlin P., Ling, Hua, Hetrick, Kurt N., Pugh, Elizabeth W., Amos, Chris, Wei, Qingyi, Wang, Li-e, Lee, Jeffrey E., Barnes, Kathleen C., Hansel, Nadia N., Mathias, Rasika, Daley, Denise, Beaty, Terri H., Scott, Alan F., Ruczinski, Ingo, Scharpf, Rob B., Bierut, Laura J., Hartz, Sarah M., Landi, Maria Teresa, Freedman, Neal D., Goldin, Lynn R., Ginsburg, David, Li, Jun, Desch, Karl C., Strom, Sara S., Blot, William J., Signorello, Lisa B., Ingles, Sue A., Chanock, Stephen J., Berndt, Sonja I., Le Marchand, Loic, Henderson, Brian E., Monroe, Kristine R, Heit, John A., de Andrade, Mariza, Armasu, Sebastian M., Regnier, Cynthia, Lowe, William L., Hayes, M. Geoffrey, Marazita, Mary L., Feingold, Eleanor, Murray, Jeffrey C., Melbye, Mads, Feenstra, Bjarke, Kang, Jae H., Wiggs, Janey L., Jarvik, Gail P., McDavid, Andrew N., Seshan, Venkatraman E., Mirel, Daniel B., Crenshaw, Andrew, Sharopova, Nataliya, Wise, Anastasia, Shen, Jess, Crosslin, David R., Levine, David M., Zheng, Xiuwen, Udren, Jenna I, Bennett, Siiri, Nelson, Sarah C., Gogarten, Stephanie M., Conomos, Matthew P., Heagerty, Patrick, Manolio, Teri, Pasquale, Louis R., Haiman, Christopher A., Caporaso, Neil, Weir, Bruce S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3366033/
https://www.ncbi.nlm.nih.gov/pubmed/22561516
http://dx.doi.org/10.1038/ng.2271

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