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Genome-wide association analyses identify 13 new susceptibility loci for generalized vitiligo
In previous linkage and genome-wide association studies we identified 17 susceptibility loci for generalized vitiligo. By a second genome-wide association study, meta-analysis, and independent replication study, we have now identified 13 additional vitiligo-associated loci, including OCA2-HERC2, a r...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3366044/ https://www.ncbi.nlm.nih.gov/pubmed/22561518 http://dx.doi.org/10.1038/ng.2272 |
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| author | Jin, Ying Birlea, Stanca A Fain, Pamela R Ferrara, Tracey M Ben, Songtao Riccardi, Sheri L Cole, Joanne B Gowan, Katherine Holland, Paulene J Bennett, Dorothy C Luiten, Rosalie M Wolkerstorfer, Albert van der Veen, JP Wietze Hartmann, Anke Eichner, Saskia Schuler, Gerold van Geel, Nanja Lambert, Jo Kemp, E Helen Gawkrodger, David J Weetman, Anthony P Taïeb, Alain Jouary, Thomas Ezzedine, Khaled Wallace, Margaret R McCormack, Wayne T Picardo, Mauro Leone, Giovanni Overbeck, Andreas Silverberg, Nanette B Spritz, Richard A |
| author_facet | Jin, Ying Birlea, Stanca A Fain, Pamela R Ferrara, Tracey M Ben, Songtao Riccardi, Sheri L Cole, Joanne B Gowan, Katherine Holland, Paulene J Bennett, Dorothy C Luiten, Rosalie M Wolkerstorfer, Albert van der Veen, JP Wietze Hartmann, Anke Eichner, Saskia Schuler, Gerold van Geel, Nanja Lambert, Jo Kemp, E Helen Gawkrodger, David J Weetman, Anthony P Taïeb, Alain Jouary, Thomas Ezzedine, Khaled Wallace, Margaret R McCormack, Wayne T Picardo, Mauro Leone, Giovanni Overbeck, Andreas Silverberg, Nanette B Spritz, Richard A |
| author_sort | Jin, Ying |
| collection | PubMed |
| description | In previous linkage and genome-wide association studies we identified 17 susceptibility loci for generalized vitiligo. By a second genome-wide association study, meta-analysis, and independent replication study, we have now identified 13 additional vitiligo-associated loci, including OCA2-HERC2, a region of 16q24.3 containing MC1R, a region of chromosome 11q21 near TYR, several immunoregulatory loci including IFIH1, CD80, CLNK, BACH2, SLA, CASP7, CD44, IKZF4, SH2B3, and a region of 22q13.2 where the causal gene remains uncertain. Functional pathway analysis shows that most vitiligo susceptibility loci encode immunoregulatory proteins or melanocyte components that likely mediate immune targeting and genetic relationships among vitiligo, malignant melanoma, and normal variation of eye, skin, and hair color. |
| format | Online Article Text |
| id | pubmed-3366044 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2012 |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-33660442012-12-01 Genome-wide association analyses identify 13 new susceptibility loci for generalized vitiligo Jin, Ying Birlea, Stanca A Fain, Pamela R Ferrara, Tracey M Ben, Songtao Riccardi, Sheri L Cole, Joanne B Gowan, Katherine Holland, Paulene J Bennett, Dorothy C Luiten, Rosalie M Wolkerstorfer, Albert van der Veen, JP Wietze Hartmann, Anke Eichner, Saskia Schuler, Gerold van Geel, Nanja Lambert, Jo Kemp, E Helen Gawkrodger, David J Weetman, Anthony P Taïeb, Alain Jouary, Thomas Ezzedine, Khaled Wallace, Margaret R McCormack, Wayne T Picardo, Mauro Leone, Giovanni Overbeck, Andreas Silverberg, Nanette B Spritz, Richard A Nat Genet Article In previous linkage and genome-wide association studies we identified 17 susceptibility loci for generalized vitiligo. By a second genome-wide association study, meta-analysis, and independent replication study, we have now identified 13 additional vitiligo-associated loci, including OCA2-HERC2, a region of 16q24.3 containing MC1R, a region of chromosome 11q21 near TYR, several immunoregulatory loci including IFIH1, CD80, CLNK, BACH2, SLA, CASP7, CD44, IKZF4, SH2B3, and a region of 22q13.2 where the causal gene remains uncertain. Functional pathway analysis shows that most vitiligo susceptibility loci encode immunoregulatory proteins or melanocyte components that likely mediate immune targeting and genetic relationships among vitiligo, malignant melanoma, and normal variation of eye, skin, and hair color. 2012-05-06 /pmc/articles/PMC3366044/ /pubmed/22561518 http://dx.doi.org/10.1038/ng.2272 Text en Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms |
| spellingShingle | Article Jin, Ying Birlea, Stanca A Fain, Pamela R Ferrara, Tracey M Ben, Songtao Riccardi, Sheri L Cole, Joanne B Gowan, Katherine Holland, Paulene J Bennett, Dorothy C Luiten, Rosalie M Wolkerstorfer, Albert van der Veen, JP Wietze Hartmann, Anke Eichner, Saskia Schuler, Gerold van Geel, Nanja Lambert, Jo Kemp, E Helen Gawkrodger, David J Weetman, Anthony P Taïeb, Alain Jouary, Thomas Ezzedine, Khaled Wallace, Margaret R McCormack, Wayne T Picardo, Mauro Leone, Giovanni Overbeck, Andreas Silverberg, Nanette B Spritz, Richard A Genome-wide association analyses identify 13 new susceptibility loci for generalized vitiligo |
| title | Genome-wide association analyses identify 13 new susceptibility loci for generalized vitiligo |
| title_full | Genome-wide association analyses identify 13 new susceptibility loci for generalized vitiligo |
| title_fullStr | Genome-wide association analyses identify 13 new susceptibility loci for generalized vitiligo |
| title_full_unstemmed | Genome-wide association analyses identify 13 new susceptibility loci for generalized vitiligo |
| title_short | Genome-wide association analyses identify 13 new susceptibility loci for generalized vitiligo |
| title_sort | genome-wide association analyses identify 13 new susceptibility loci for generalized vitiligo |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3366044/ https://www.ncbi.nlm.nih.gov/pubmed/22561518 http://dx.doi.org/10.1038/ng.2272 |
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