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Inhibition of Bax protects neuronal cells from oligomeric Aβ neurotoxicity

Although oligomeric β-amyloid (Aβ) has been suggested to have an important role in Alzheimer disease (AD), the mechanism(s) of how Aβ induces neuronal cell death has not been fully identified. The balance of pro- and anti-apoptotic Bcl-2 family proteins (e.g., Bcl-2 and Bcl-w versus Bad, Bim and Bax...

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Detalles Bibliográficos
Autores principales:	Kudo, W, Lee, H-P, Smith, M A, Zhu, X, Matsuyama, S, Lee, H-g
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2012
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3366077/ https://www.ncbi.nlm.nih.gov/pubmed/22592316 http://dx.doi.org/10.1038/cddis.2012.43

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