Binding of carbon nanotube to BMP receptor 2 enhances cell differentiation and inhibits apoptosis via regulating bHLH transcription factors

Biomaterials that can drive stem cells to an appropriate differentiation level and decrease apoptosis of transplanted cells are needed in regenerative medicine. Nanomaterials are promising novel materials for such applications. Here we reported that carboxylated multiwalled carbon nanotube (MWCNT 1)...

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Detalles Bibliográficos
Autores principales: Zhang, Y, Mu, Q, Zhou, H, Vrijens, K, Roussel, M F, Jiang, G, Yan, B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2012
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3366082/
https://www.ncbi.nlm.nih.gov/pubmed/22573038
http://dx.doi.org/10.1038/cddis.2012.48
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author Zhang, Y
Mu, Q
Zhou, H
Vrijens, K
Roussel, M F
Jiang, G
Yan, B
author_facet Zhang, Y
Mu, Q
Zhou, H
Vrijens, K
Roussel, M F
Jiang, G
Yan, B
author_sort Zhang, Y
collection PubMed
description Biomaterials that can drive stem cells to an appropriate differentiation level and decrease apoptosis of transplanted cells are needed in regenerative medicine. Nanomaterials are promising novel materials for such applications. Here we reported that carboxylated multiwalled carbon nanotube (MWCNT 1) promotes myogenic differentiation of mouse myoblast cells and inhibits cell apoptosis under the differentiation conditions by regulating basic helix-loop-helix transcription factors. MWCNT 1 attenuates bone morphogenetic protein receptor (BMPR) signaling activity by binding to BMPR2 and attenuating the phosphorylation of BMPR1. This molecular understanding allowed us to tune stem cell differentiation to various levels by chemical modifications, demonstrating human control of biological activities of nanoparticles and opening an avenue for potential applications of nanomaterials in regenerative medicine.
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spelling pubmed-33660822012-06-04 Binding of carbon nanotube to BMP receptor 2 enhances cell differentiation and inhibits apoptosis via regulating bHLH transcription factors Zhang, Y Mu, Q Zhou, H Vrijens, K Roussel, M F Jiang, G Yan, B Cell Death Dis Original Article Biomaterials that can drive stem cells to an appropriate differentiation level and decrease apoptosis of transplanted cells are needed in regenerative medicine. Nanomaterials are promising novel materials for such applications. Here we reported that carboxylated multiwalled carbon nanotube (MWCNT 1) promotes myogenic differentiation of mouse myoblast cells and inhibits cell apoptosis under the differentiation conditions by regulating basic helix-loop-helix transcription factors. MWCNT 1 attenuates bone morphogenetic protein receptor (BMPR) signaling activity by binding to BMPR2 and attenuating the phosphorylation of BMPR1. This molecular understanding allowed us to tune stem cell differentiation to various levels by chemical modifications, demonstrating human control of biological activities of nanoparticles and opening an avenue for potential applications of nanomaterials in regenerative medicine. Nature Publishing Group 2012-05 2012-05-10 /pmc/articles/PMC3366082/ /pubmed/22573038 http://dx.doi.org/10.1038/cddis.2012.48 Text en Copyright © 2012 Macmillan Publishers Limited http://creativecommons.org/licenses/by-nc-nd/3.0/ This work is licensed under the Creative Commons Attribution-NonCommercial-No Derivative Works 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/
spellingShingle Original Article
Zhang, Y
Mu, Q
Zhou, H
Vrijens, K
Roussel, M F
Jiang, G
Yan, B
Binding of carbon nanotube to BMP receptor 2 enhances cell differentiation and inhibits apoptosis via regulating bHLH transcription factors
title Binding of carbon nanotube to BMP receptor 2 enhances cell differentiation and inhibits apoptosis via regulating bHLH transcription factors
title_full Binding of carbon nanotube to BMP receptor 2 enhances cell differentiation and inhibits apoptosis via regulating bHLH transcription factors
title_fullStr Binding of carbon nanotube to BMP receptor 2 enhances cell differentiation and inhibits apoptosis via regulating bHLH transcription factors
title_full_unstemmed Binding of carbon nanotube to BMP receptor 2 enhances cell differentiation and inhibits apoptosis via regulating bHLH transcription factors
title_short Binding of carbon nanotube to BMP receptor 2 enhances cell differentiation and inhibits apoptosis via regulating bHLH transcription factors
title_sort binding of carbon nanotube to bmp receptor 2 enhances cell differentiation and inhibits apoptosis via regulating bhlh transcription factors
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3366082/
https://www.ncbi.nlm.nih.gov/pubmed/22573038
http://dx.doi.org/10.1038/cddis.2012.48
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