LEDGF gene silencing impairs the tumorigenicity of prostate cancer DU145 cells by abating the expression of Hsp27 and activation of the Akt/ERK signaling pathway

Lens epithelium-derived growth factor (LEDGF) maintains survival pathways by augmenting the transcription of stress-response genes such as small heat-shock protein 27. Recently, aberrant expression of LEDGF was found in prostate cancer (PC). Herein, we showed that LEDGF overexpression upregulated Hs...

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Detalles Bibliográficos
Autores principales: Bhargavan, B, Fatma, N, Chhunchha, B, Singh, V, Kubo, E, Singh, D P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2012
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3366088/
https://www.ncbi.nlm.nih.gov/pubmed/22647853
http://dx.doi.org/10.1038/cddis.2012.57

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