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Deficient sustained attention to response task and P300 characteristics in early Huntington’s disease

Evidence for the extent and nature of attentional impairment in premanifest and manifest Huntington’s disease (HD) is inconsistent. Understanding such impairments may help to better understand early functional changes in HD and could have consequences concerning care for HD patients. We investigated...

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Autores principales: Hart, E. P., Dumas, E. M., Reijntjes, R. H. A. M., van der Hiele, K., van den Bogaard, S. J. A., Middelkoop, H. A. M., Roos, R. A. C., van Dijk, J. G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer-Verlag 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3366183/
https://www.ncbi.nlm.nih.gov/pubmed/22143614
http://dx.doi.org/10.1007/s00415-011-6334-0
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author Hart, E. P.
Dumas, E. M.
Reijntjes, R. H. A. M.
van der Hiele, K.
van den Bogaard, S. J. A.
Middelkoop, H. A. M.
Roos, R. A. C.
van Dijk, J. G.
author_facet Hart, E. P.
Dumas, E. M.
Reijntjes, R. H. A. M.
van der Hiele, K.
van den Bogaard, S. J. A.
Middelkoop, H. A. M.
Roos, R. A. C.
van Dijk, J. G.
author_sort Hart, E. P.
collection PubMed
description Evidence for the extent and nature of attentional impairment in premanifest and manifest Huntington’s disease (HD) is inconsistent. Understanding such impairments may help to better understand early functional changes in HD and could have consequences concerning care for HD patients. We investigated attentional control in both early and premanifest HD. We studied 17 early HD subjects (mean age: 51 years), 12 premanifest HD subjects (mean age: 43 years), and 15 healthy controls (mean age: 51 years), using the sustained attention to response task (SART), a simple Go/No-go test reflecting attentional and inhibitory processes through reaction time (RT) and error rates. Simultaneously recorded EEG yielded P300 amplitudes and latencies. The early HD group made more Go errors (p < 0.001) and reacted slower (p < 0.005) than the other groups. The RT pattern during the SART was remarkably different for early HD subjects compared to the other two groups (p < 0.005), apparent as significant post-error slowing. P300 data showed that for early HD the No-go amplitude was lower than for the other two groups (p < 0.05). Subjects with early HD showed a reduced capacity to effectively control attention. They proved unable to resume the task directly after having made an error, and need more time to return to pre-error performance levels. No attentional control deficits were found for the premanifest HD group.
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spelling pubmed-33661832012-06-13 Deficient sustained attention to response task and P300 characteristics in early Huntington’s disease Hart, E. P. Dumas, E. M. Reijntjes, R. H. A. M. van der Hiele, K. van den Bogaard, S. J. A. Middelkoop, H. A. M. Roos, R. A. C. van Dijk, J. G. J Neurol Original Communication Evidence for the extent and nature of attentional impairment in premanifest and manifest Huntington’s disease (HD) is inconsistent. Understanding such impairments may help to better understand early functional changes in HD and could have consequences concerning care for HD patients. We investigated attentional control in both early and premanifest HD. We studied 17 early HD subjects (mean age: 51 years), 12 premanifest HD subjects (mean age: 43 years), and 15 healthy controls (mean age: 51 years), using the sustained attention to response task (SART), a simple Go/No-go test reflecting attentional and inhibitory processes through reaction time (RT) and error rates. Simultaneously recorded EEG yielded P300 amplitudes and latencies. The early HD group made more Go errors (p < 0.001) and reacted slower (p < 0.005) than the other groups. The RT pattern during the SART was remarkably different for early HD subjects compared to the other two groups (p < 0.005), apparent as significant post-error slowing. P300 data showed that for early HD the No-go amplitude was lower than for the other two groups (p < 0.05). Subjects with early HD showed a reduced capacity to effectively control attention. They proved unable to resume the task directly after having made an error, and need more time to return to pre-error performance levels. No attentional control deficits were found for the premanifest HD group. Springer-Verlag 2011-12-06 2012 /pmc/articles/PMC3366183/ /pubmed/22143614 http://dx.doi.org/10.1007/s00415-011-6334-0 Text en © The Author(s) 2011 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.
spellingShingle Original Communication
Hart, E. P.
Dumas, E. M.
Reijntjes, R. H. A. M.
van der Hiele, K.
van den Bogaard, S. J. A.
Middelkoop, H. A. M.
Roos, R. A. C.
van Dijk, J. G.
Deficient sustained attention to response task and P300 characteristics in early Huntington’s disease
title Deficient sustained attention to response task and P300 characteristics in early Huntington’s disease
title_full Deficient sustained attention to response task and P300 characteristics in early Huntington’s disease
title_fullStr Deficient sustained attention to response task and P300 characteristics in early Huntington’s disease
title_full_unstemmed Deficient sustained attention to response task and P300 characteristics in early Huntington’s disease
title_short Deficient sustained attention to response task and P300 characteristics in early Huntington’s disease
title_sort deficient sustained attention to response task and p300 characteristics in early huntington’s disease
topic Original Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3366183/
https://www.ncbi.nlm.nih.gov/pubmed/22143614
http://dx.doi.org/10.1007/s00415-011-6334-0
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