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Biology and Biotechnology of Follicle Development

Growth and development of ovarian follicles require a series of coordinated events that induce morphological and functional changes within the follicle, leading to cell differentiation and oocyte development. The preantral early antral follicle transition is the stage of follicular development durin...

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Autores principales: Palma, Gustavo Adolfo, Argañaraz, Martin Eduardo, Barrera, Antonio Daniel, Rodler, Daniela, Mutto, Adrian Ángel, Sinowatz, Fred
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Scientific World Journal 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3366219/
https://www.ncbi.nlm.nih.gov/pubmed/22666170
http://dx.doi.org/10.1100/2012/938138
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author Palma, Gustavo Adolfo
Argañaraz, Martin Eduardo
Barrera, Antonio Daniel
Rodler, Daniela
Mutto, Adrian Ángel
Sinowatz, Fred
author_facet Palma, Gustavo Adolfo
Argañaraz, Martin Eduardo
Barrera, Antonio Daniel
Rodler, Daniela
Mutto, Adrian Ángel
Sinowatz, Fred
author_sort Palma, Gustavo Adolfo
collection PubMed
description Growth and development of ovarian follicles require a series of coordinated events that induce morphological and functional changes within the follicle, leading to cell differentiation and oocyte development. The preantral early antral follicle transition is the stage of follicular development during which gonadotropin dependence is obtained and the progression into growing or atresia of the follicle is made. Follicular growth during this period is tightly regulated by oocyte-granulosatheca cell interactions. A cluster of early expressed genes is required for normal folliculogenesis. Granulosa cell factors stimulate the recruitment of theca cells from cortical stromal cells. Thecal factors promote granulosa cell proliferation and suppress granulosa cell apoptosis. Cell-cell and cell-extracellular matrix interactions influence the production of growth factors in the different follicular compartments (oocyte, granulosa, and theca cells). Several autocrine and paracrine factors are involved in follicular growth and differentiation; their activity is present even at the time of ovulation, decreasing the gap junction communication, and stimulating the theca cell proliferation. In addition, the identification of the factors that promote follicular growth from the preantral stage to the small antral stage may provide important information for the identification for assisted reproduction techniques.
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spelling pubmed-33662192012-06-04 Biology and Biotechnology of Follicle Development Palma, Gustavo Adolfo Argañaraz, Martin Eduardo Barrera, Antonio Daniel Rodler, Daniela Mutto, Adrian Ángel Sinowatz, Fred ScientificWorldJournal Review Article Growth and development of ovarian follicles require a series of coordinated events that induce morphological and functional changes within the follicle, leading to cell differentiation and oocyte development. The preantral early antral follicle transition is the stage of follicular development during which gonadotropin dependence is obtained and the progression into growing or atresia of the follicle is made. Follicular growth during this period is tightly regulated by oocyte-granulosatheca cell interactions. A cluster of early expressed genes is required for normal folliculogenesis. Granulosa cell factors stimulate the recruitment of theca cells from cortical stromal cells. Thecal factors promote granulosa cell proliferation and suppress granulosa cell apoptosis. Cell-cell and cell-extracellular matrix interactions influence the production of growth factors in the different follicular compartments (oocyte, granulosa, and theca cells). Several autocrine and paracrine factors are involved in follicular growth and differentiation; their activity is present even at the time of ovulation, decreasing the gap junction communication, and stimulating the theca cell proliferation. In addition, the identification of the factors that promote follicular growth from the preantral stage to the small antral stage may provide important information for the identification for assisted reproduction techniques. The Scientific World Journal 2012-05-22 /pmc/articles/PMC3366219/ /pubmed/22666170 http://dx.doi.org/10.1100/2012/938138 Text en Copyright © 2012 Gustavo Adolfo Palma et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Palma, Gustavo Adolfo
Argañaraz, Martin Eduardo
Barrera, Antonio Daniel
Rodler, Daniela
Mutto, Adrian Ángel
Sinowatz, Fred
Biology and Biotechnology of Follicle Development
title Biology and Biotechnology of Follicle Development
title_full Biology and Biotechnology of Follicle Development
title_fullStr Biology and Biotechnology of Follicle Development
title_full_unstemmed Biology and Biotechnology of Follicle Development
title_short Biology and Biotechnology of Follicle Development
title_sort biology and biotechnology of follicle development
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3366219/
https://www.ncbi.nlm.nih.gov/pubmed/22666170
http://dx.doi.org/10.1100/2012/938138
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