Ectopic Fat and Insulin Resistance: Pathophysiology and Effect of Diet and Lifestyle Interventions

The storage of triglyceride (TG) droplets in nonadipose tissues is called ectopic fat storage. Ectopic fat is associated with insulin resistance and type 2 diabetes mellitus (T2DM). Not the triglycerides per se but the accumulation of intermediates of lipid metabolism in organs, such as the liver, s...

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Autores principales: Snel, M., Jonker, J. T., Schoones, J., Lamb, H., de Roos, A., Pijl, H., Smit, J. W. A., Meinders, A. E., Jazet, I. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3366269/
https://www.ncbi.nlm.nih.gov/pubmed/22675355
http://dx.doi.org/10.1155/2012/983814
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author Snel, M.
Jonker, J. T.
Schoones, J.
Lamb, H.
de Roos, A.
Pijl, H.
Smit, J. W. A.
Meinders, A. E.
Jazet, I. M.
author_facet Snel, M.
Jonker, J. T.
Schoones, J.
Lamb, H.
de Roos, A.
Pijl, H.
Smit, J. W. A.
Meinders, A. E.
Jazet, I. M.
author_sort Snel, M.
collection PubMed
description The storage of triglyceride (TG) droplets in nonadipose tissues is called ectopic fat storage. Ectopic fat is associated with insulin resistance and type 2 diabetes mellitus (T2DM). Not the triglycerides per se but the accumulation of intermediates of lipid metabolism in organs, such as the liver, skeletal muscle, and heart seem to disrupt metabolic processes and impair organ function. We describe the mechanisms of ectopic fat depositions in the liver, skeletal muscle, and in and around the heart and the consequences for each organs function. In addition, we systematically reviewed the literature for the effects of diet-induced weight loss and exercise on ectopic fat depositions.
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spelling pubmed-33662692012-06-06 Ectopic Fat and Insulin Resistance: Pathophysiology and Effect of Diet and Lifestyle Interventions Snel, M. Jonker, J. T. Schoones, J. Lamb, H. de Roos, A. Pijl, H. Smit, J. W. A. Meinders, A. E. Jazet, I. M. Int J Endocrinol Review Article The storage of triglyceride (TG) droplets in nonadipose tissues is called ectopic fat storage. Ectopic fat is associated with insulin resistance and type 2 diabetes mellitus (T2DM). Not the triglycerides per se but the accumulation of intermediates of lipid metabolism in organs, such as the liver, skeletal muscle, and heart seem to disrupt metabolic processes and impair organ function. We describe the mechanisms of ectopic fat depositions in the liver, skeletal muscle, and in and around the heart and the consequences for each organs function. In addition, we systematically reviewed the literature for the effects of diet-induced weight loss and exercise on ectopic fat depositions. Hindawi Publishing Corporation 2012 2012-05-24 /pmc/articles/PMC3366269/ /pubmed/22675355 http://dx.doi.org/10.1155/2012/983814 Text en Copyright © 2012 M. Snel et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Snel, M.
Jonker, J. T.
Schoones, J.
Lamb, H.
de Roos, A.
Pijl, H.
Smit, J. W. A.
Meinders, A. E.
Jazet, I. M.
Ectopic Fat and Insulin Resistance: Pathophysiology and Effect of Diet and Lifestyle Interventions
title Ectopic Fat and Insulin Resistance: Pathophysiology and Effect of Diet and Lifestyle Interventions
title_full Ectopic Fat and Insulin Resistance: Pathophysiology and Effect of Diet and Lifestyle Interventions
title_fullStr Ectopic Fat and Insulin Resistance: Pathophysiology and Effect of Diet and Lifestyle Interventions
title_full_unstemmed Ectopic Fat and Insulin Resistance: Pathophysiology and Effect of Diet and Lifestyle Interventions
title_short Ectopic Fat and Insulin Resistance: Pathophysiology and Effect of Diet and Lifestyle Interventions
title_sort ectopic fat and insulin resistance: pathophysiology and effect of diet and lifestyle interventions
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3366269/
https://www.ncbi.nlm.nih.gov/pubmed/22675355
http://dx.doi.org/10.1155/2012/983814
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