Tyrosine Phosphorylation of Botulinum Neurotoxin Protease Domains

Botulinum neurotoxins are most potent of all toxins. Their N-terminal light chain domain (Lc) translocates into peripheral cholinergic neurons to exert its endoproteolytic action leading to muscle paralysis. Therapeutic development against these toxins is a major challenge due to their in vitro and...

Descripción completa

Detalles Bibliográficos
Autores principales: Toth, Stephen, Brueggmann, Ernst E., Oyler, George A., Smith, Leonard A., Hines, Harry B., Ahmed, S. Ashraf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Research Foundation 2012
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3366388/
https://www.ncbi.nlm.nih.gov/pubmed/22675300
http://dx.doi.org/10.3389/fphar.2012.00102

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3366388/
https://www.ncbi.nlm.nih.gov/pubmed/22675300
http://dx.doi.org/10.3389/fphar.2012.00102

Ejemplares similares