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Tyrosine Phosphorylation of Botulinum Neurotoxin Protease Domains

Botulinum neurotoxins are most potent of all toxins. Their N-terminal light chain domain (Lc) translocates into peripheral cholinergic neurons to exert its endoproteolytic action leading to muscle paralysis. Therapeutic development against these toxins is a major challenge due to their in vitro and...

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Detalles Bibliográficos
Autores principales:	Toth, Stephen, Brueggmann, Ernst E., Oyler, George A., Smith, Leonard A., Hines, Harry B., Ahmed, S. Ashraf
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Research Foundation 2012
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3366388/ https://www.ncbi.nlm.nih.gov/pubmed/22675300 http://dx.doi.org/10.3389/fphar.2012.00102

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