TH17 Cells in Autoimmunity and Immunodeficiency: Protective or Pathogenic?

In 2005 a newly discovered T helper cell subset that secreted interleukin (IL)-17 became the center of attention in immunology. Initial studies painted Th17 cells as the culprit for destruction in many different autoimmune and auto-inflammatory diseases. Subsequently, the discovery of patients with...

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Autores principales: Marwaha, Ashish K., Leung, Nicole J., McMurchy, Alicia N., Levings, Megan K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Research Foundation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3366440/
https://www.ncbi.nlm.nih.gov/pubmed/22675324
http://dx.doi.org/10.3389/fimmu.2012.00129
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author Marwaha, Ashish K.
Leung, Nicole J.
McMurchy, Alicia N.
Levings, Megan K.
author_facet Marwaha, Ashish K.
Leung, Nicole J.
McMurchy, Alicia N.
Levings, Megan K.
author_sort Marwaha, Ashish K.
collection PubMed
description In 2005 a newly discovered T helper cell subset that secreted interleukin (IL)-17 became the center of attention in immunology. Initial studies painted Th17 cells as the culprit for destruction in many different autoimmune and auto-inflammatory diseases. Subsequently, the discovery of patients with primary immunodeficiencies in the IL-17 pathway taught us that Th17 cells have a critical role in defense against certain fungal and bacterial infections. Moreover, the paradoxical exacerbation of Crohn’s disease in the clinical trials of a Secukinumab (AIN457), a fully human neutralizing antibody to IL-17A, has cast into doubt a universal pro-inflammatory and harmful role for Th17 cells. Evidence now suggests that depending on the environment Th17 cells can alter their differentiation program, ultimately giving rise to either protective or pro-inflammatory cells. In this review we will summarize the evidence from patients with immunodeficiencies, autoimmune, or auto-inflammatory diseases that teaches us how the pro-inflammatory versus protective function of Th17 cells varies within the context of different human diseases.
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spelling pubmed-33664402012-06-06 TH17 Cells in Autoimmunity and Immunodeficiency: Protective or Pathogenic? Marwaha, Ashish K. Leung, Nicole J. McMurchy, Alicia N. Levings, Megan K. Front Immunol Immunology In 2005 a newly discovered T helper cell subset that secreted interleukin (IL)-17 became the center of attention in immunology. Initial studies painted Th17 cells as the culprit for destruction in many different autoimmune and auto-inflammatory diseases. Subsequently, the discovery of patients with primary immunodeficiencies in the IL-17 pathway taught us that Th17 cells have a critical role in defense against certain fungal and bacterial infections. Moreover, the paradoxical exacerbation of Crohn’s disease in the clinical trials of a Secukinumab (AIN457), a fully human neutralizing antibody to IL-17A, has cast into doubt a universal pro-inflammatory and harmful role for Th17 cells. Evidence now suggests that depending on the environment Th17 cells can alter their differentiation program, ultimately giving rise to either protective or pro-inflammatory cells. In this review we will summarize the evidence from patients with immunodeficiencies, autoimmune, or auto-inflammatory diseases that teaches us how the pro-inflammatory versus protective function of Th17 cells varies within the context of different human diseases. Frontiers Research Foundation 2012-06-04 /pmc/articles/PMC3366440/ /pubmed/22675324 http://dx.doi.org/10.3389/fimmu.2012.00129 Text en Copyright © 2012 Marwaha, Leung, McMurchy and Levings. http://www.frontiersin.org/licenseagreement This is an openaccess article distributed under the terms of the Creative Commons Attribution Non Commercial License, which permits non-commercial use, distribution, and reproduction in other forums, provided the original authors and source are credited.
spellingShingle Immunology
Marwaha, Ashish K.
Leung, Nicole J.
McMurchy, Alicia N.
Levings, Megan K.
TH17 Cells in Autoimmunity and Immunodeficiency: Protective or Pathogenic?
title TH17 Cells in Autoimmunity and Immunodeficiency: Protective or Pathogenic?
title_full TH17 Cells in Autoimmunity and Immunodeficiency: Protective or Pathogenic?
title_fullStr TH17 Cells in Autoimmunity and Immunodeficiency: Protective or Pathogenic?
title_full_unstemmed TH17 Cells in Autoimmunity and Immunodeficiency: Protective or Pathogenic?
title_short TH17 Cells in Autoimmunity and Immunodeficiency: Protective or Pathogenic?
title_sort th17 cells in autoimmunity and immunodeficiency: protective or pathogenic?
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3366440/
https://www.ncbi.nlm.nih.gov/pubmed/22675324
http://dx.doi.org/10.3389/fimmu.2012.00129
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