TH17 Cells in Autoimmunity and Immunodeficiency: Protective or Pathogenic?
In 2005 a newly discovered T helper cell subset that secreted interleukin (IL)-17 became the center of attention in immunology. Initial studies painted Th17 cells as the culprit for destruction in many different autoimmune and auto-inflammatory diseases. Subsequently, the discovery of patients with...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Research Foundation
2012
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3366440/ https://www.ncbi.nlm.nih.gov/pubmed/22675324 http://dx.doi.org/10.3389/fimmu.2012.00129 |
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author | Marwaha, Ashish K. Leung, Nicole J. McMurchy, Alicia N. Levings, Megan K. |
author_facet | Marwaha, Ashish K. Leung, Nicole J. McMurchy, Alicia N. Levings, Megan K. |
author_sort | Marwaha, Ashish K. |
collection | PubMed |
description | In 2005 a newly discovered T helper cell subset that secreted interleukin (IL)-17 became the center of attention in immunology. Initial studies painted Th17 cells as the culprit for destruction in many different autoimmune and auto-inflammatory diseases. Subsequently, the discovery of patients with primary immunodeficiencies in the IL-17 pathway taught us that Th17 cells have a critical role in defense against certain fungal and bacterial infections. Moreover, the paradoxical exacerbation of Crohn’s disease in the clinical trials of a Secukinumab (AIN457), a fully human neutralizing antibody to IL-17A, has cast into doubt a universal pro-inflammatory and harmful role for Th17 cells. Evidence now suggests that depending on the environment Th17 cells can alter their differentiation program, ultimately giving rise to either protective or pro-inflammatory cells. In this review we will summarize the evidence from patients with immunodeficiencies, autoimmune, or auto-inflammatory diseases that teaches us how the pro-inflammatory versus protective function of Th17 cells varies within the context of different human diseases. |
format | Online Article Text |
id | pubmed-3366440 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Frontiers Research Foundation |
record_format | MEDLINE/PubMed |
spelling | pubmed-33664402012-06-06 TH17 Cells in Autoimmunity and Immunodeficiency: Protective or Pathogenic? Marwaha, Ashish K. Leung, Nicole J. McMurchy, Alicia N. Levings, Megan K. Front Immunol Immunology In 2005 a newly discovered T helper cell subset that secreted interleukin (IL)-17 became the center of attention in immunology. Initial studies painted Th17 cells as the culprit for destruction in many different autoimmune and auto-inflammatory diseases. Subsequently, the discovery of patients with primary immunodeficiencies in the IL-17 pathway taught us that Th17 cells have a critical role in defense against certain fungal and bacterial infections. Moreover, the paradoxical exacerbation of Crohn’s disease in the clinical trials of a Secukinumab (AIN457), a fully human neutralizing antibody to IL-17A, has cast into doubt a universal pro-inflammatory and harmful role for Th17 cells. Evidence now suggests that depending on the environment Th17 cells can alter their differentiation program, ultimately giving rise to either protective or pro-inflammatory cells. In this review we will summarize the evidence from patients with immunodeficiencies, autoimmune, or auto-inflammatory diseases that teaches us how the pro-inflammatory versus protective function of Th17 cells varies within the context of different human diseases. Frontiers Research Foundation 2012-06-04 /pmc/articles/PMC3366440/ /pubmed/22675324 http://dx.doi.org/10.3389/fimmu.2012.00129 Text en Copyright © 2012 Marwaha, Leung, McMurchy and Levings. http://www.frontiersin.org/licenseagreement This is an openaccess article distributed under the terms of the Creative Commons Attribution Non Commercial License, which permits non-commercial use, distribution, and reproduction in other forums, provided the original authors and source are credited. |
spellingShingle | Immunology Marwaha, Ashish K. Leung, Nicole J. McMurchy, Alicia N. Levings, Megan K. TH17 Cells in Autoimmunity and Immunodeficiency: Protective or Pathogenic? |
title | TH17 Cells in Autoimmunity and Immunodeficiency: Protective or Pathogenic? |
title_full | TH17 Cells in Autoimmunity and Immunodeficiency: Protective or Pathogenic? |
title_fullStr | TH17 Cells in Autoimmunity and Immunodeficiency: Protective or Pathogenic? |
title_full_unstemmed | TH17 Cells in Autoimmunity and Immunodeficiency: Protective or Pathogenic? |
title_short | TH17 Cells in Autoimmunity and Immunodeficiency: Protective or Pathogenic? |
title_sort | th17 cells in autoimmunity and immunodeficiency: protective or pathogenic? |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3366440/ https://www.ncbi.nlm.nih.gov/pubmed/22675324 http://dx.doi.org/10.3389/fimmu.2012.00129 |
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