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All in the Family: How the APPs Regulate Neurogenesis

Recent intriguing evidence suggests that metabolites of amyloid precursor protein (APP), mutated in familial forms of Alzheimer’s disease (AD), play critical roles in developmental and postnatal neurogenesis. Of note is soluble APPα (sAPPα) that regulates neural progenitor cell proliferation. The AP...

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Detalles Bibliográficos
Autores principales: Lazarov, Orly, Demars, Michael P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Research Foundation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3366480/
https://www.ncbi.nlm.nih.gov/pubmed/22675290
http://dx.doi.org/10.3389/fnins.2012.00081